Anti-TTC4 antibody produced in rabbit

Tetratricopeptide repeat domain 4 (TTC4) is a novel tumor suppressor gene, mapped to human chromosome 1p31. TTC4 belongs to the tetratricopeptide repeat (TPR) family. The encoded protein is ubiquitously expressed and contains tetratricopeptide repeats.

tetratricopeptide repeat domain 4 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Tetratricopeptide repeat domain 4 (TTC4) acts as a key component of complex containing the histone acetyltransferase males absent on the first (Mof)/MYST1 complex and in the assembly of transcription factor for polymerase III B (TFIIIB). TTC4 also functions as an heat shock protein 90 (Hsp90) binding protein and links Hsp90 activity to replication. Genetic variation in the gene is associated with the development of malignant melanoma of the skin. In addition, loss of the gene function results in breast cancer.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Corresponding Antigen APREST83648

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