Anti-COL4A3BP antibody produced in rabbit

Collagen type IV alpha-3-binding protein (COL4A3BP), also called as goodpasture antigen-binding protein or ceramide transfer protein (CERT), is a 68 kDa protein with N-terminal pleckstrin homology (PH), a central domain and a C-terminal steroidogenic acute regulatory protein-related lipid transfer (START) domain. COL4A3BP gene has 17 exons and is mapped to human chromosome 5q13.3.

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Ceramide transfer protein (CERT) binds to phosphoinositide through its pleckstrin domain. CERT interacts with ceramide via steroidogenic acute regulatory protein-related lipid transfer domain (START) and mediates ceramide transport for sphingomyelin synthesis from endoplasmic reticulum to Golgi complex. Mutations in the COL4A3BP may contribute to intellectual disability.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Corresponding Antigen APREST89449.

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