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Merck
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SAB3500093

Anti-JMJD1A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-JHDM2A, Anti-JHMD2A, Anti-KDM3A, Anti-Lysine-specific demethylase 3A, Anti-TSGA

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
2

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 145 kDa

species reactivity

human, mouse, rat

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

NCBI accession no.

NP_060903

UniProt accession no.

Q9Y4C1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KDM3A(55818)

General description

The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. At least two isoforms of JMJD1A are known to exist. This antibody will not cross-react with JMJD1B or JMJD1C.

Immunogen

JMJD1A antibody was raised against a 16 amino acid peptide from near the amino terminus of human JMJD1A.

Biochem/physiol Actions

Jumonji domain containing 1A protein (JMJD1A) is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of signal transducer and activator of transcription 3 (STAT3), a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells. Decreased JMJD1A expression is correlated with the differentiation of cultured mES cells following the removal of the cytokine leukemia inhibitory factor (LIF). These findings suggest that JMJD1A might be a signaling molecule having a role in maintaining pluripotency in embryonic stem cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500093.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
53650903

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Targeting Histone Demethylases
Dante Rotili
Genes & Cancer (2011)
Identification of Jmjd1a as a STAT3 downstream gene in mES cells.
Ko SY
Cell Structure and Function, 31(2), 53-62 (2006)

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