917109
2-(3-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid
Synonym(s):
Semi-flexible linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C18H25NO4
CAS Number:
Molecular Weight:
319.40
UNSPSC Code:
12352106
Form:
powder
form
powder
Quality Level
reaction suitability
reagent type: linker
functional group
Boc, carboxylic acid
storage temp.
2-8°C
SMILES string
O=C(N(CC1)CCC1C2=CC(CC(O)=O)=CC=C2)OC(C)(C)C
Application
2-(3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 917109-100MG | 04061842593460 |