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Drug delivery
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Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture
Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic
Smart Oligonucleotide Delivery by Multifunctional Block Copolymers
Kanjiro Miyata (The University of Tokyo, Japan) provides insights on the rational design of polymeric materials for “smart” oligonucleotide delivery.
Poly(Glycerol Sebacate) in Tissue Engineering and Regenerative Medicine
The world of commercial biomaterials has stagnated over the past 30 years as few materials have successfully transitioned from the bench to clinical use. Synthetic aliphatic polyesters have continued to dominate the field of resorbable biomaterials due to their long
Chemistry in (Bio)Materials Science
"Click" Chemistry in (Bio)Materials Science
Recent Progress on Nonviral Delivery Carriers for CRISPR/Cas9 Systems
The CRISPR/Cas9 system has recently emerged as a highly specific, efficient, and versatile gene editing technology that can be utilized to build disease models and correct diseased genes. Safe and effective delivery vectors for the CRISPR/Cas9 system are in critical
Functional Biomaterials Synthesized by Double-Head Polymerization Agents
Over the past two decades, the rapid advance of controlled living polymerization (CLP) techniques.
Smart Nanofiber Meshes as a Local Drug Delivery Platform
Professor Mitsuhiro Ebara provides insights on several types of smart nanofiber mesh systems that have been explored for different drug delivery purposes.
Polymersomes for Drug Delivery
The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.
Halloysite Nanotubes Applications in Nanomaterials Research
Halloysite Nanotubes in Nanomaterials Research. Halloysite, a naturally occurring aluminosilicate nanotube, has been undeservedly forgotten.
Tools for PEGylation
Polyethylene glycol (PEG) reagents offer numerous favorable characteristics, including high water solubility, high mobility in solution, lack of toxicity and immunogenicity, and ready clearance from the body.
Preparation of Chitosan Microparticles by Spray Drying
Microparticles with controlled size and morphology are of significant interest in the fields of drug delivery and biopharmaceuticals. The objective of this study was to assess the effect of processing parameters on the ability to control the size and distribution
Functionalized PEI and Its Role in Gene Therapy
Gene therapy has become one of the most discussed techniques in biomedical research in recent years.
Solubility Enhancement of Poorly Water Soluble Molecules Using Dendrimers
Environmental concerns are driving the replacement of volatile organic solvents by water and aqueous mixtures. This change often creates challenges because many organic molecules show low water solubility.
Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids
The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1Mn
What Are Biomaterials?
Biocompatible / Biodegradable Polymer Tutorial
Polyethylene Glycol Building Blocks for PEGylation
Sigma-Aldrich.com presents an article regarding Polyethylene Glycol Building Blocks for PEGylation.
Biodegradable Aliphatic Polyesters for Drug Delivery
Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.
Iron Oxide Nanoparticles, Characteristics and Applications
Iron oxide (IO) nanoparticles consist of maghemite (γ-Fe2O3) and/or magnetite (Fe3O4) particles with diameters ranging from 1 and 100 nanometer and find applications in magnetic data storage, biosensing, drug-delivery etc.
Degradex® Microspheres and Nanoparticles for Drug Delivery Research and Formulation Development
Study on how Degradex® PLGA microspheres and nanoparticles can be used for drug delivery research and formulation development.
Polyelectrolyte Multilayer Films and Membrane Functionalization
We present an article that discusses two applications in particular; first, using these layers as polyelectrolyte membranes to control permeability.
Layer-by-Layer (LbL) Assembly, A "Gentle Yet Flexible" Method Toward Functional Biomaterials
Recently, layer-by-layer (LbL) assembly has emerged as a versatile, gentle and, simple method for immobilization of functional molecules in an easily controllable thin film morphology.1,2 In this short review, we introduce recent advances in functional systems fabricated by using the
Solubility enhancement of hydrophobic drugs via drug-loaded micelles using biodegradable PEG- polyester diblock copolymers
One of the common difficulties with intravenous drug delivery is low solubility of the drug. The requirement for large quantities of saline to dissolve such materials limits their clinical use, and one solution for this problem that has recently generated
Poly(2-oxazoline)s (POx) in Biomedical Applications
Poly(2-oxazoline)s (POx) can be viewed as conformational isomers of polypeptides. They are synthesized via living cationic ringopening polymerization (LCROP) of 2-oxazolines and were almost simultaneously discovered in 1966 by the groups of Litt, Tomalia, Fukui and Seeliger.
Electrospun Nanofibers for Drug Delivery Systems
Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.
Functional Polymers for Biomedical Applications
Wide range of functional polymers for biomedical applications have been synthesized and structurally characterized. Several classes of polymers including biodegradable polymers, hydrophilic & amphiphilic polymers, and stimuli responsive polymers have been prepared using controlled and directed functionalization
Fluorescent Microparticles and Nanobeads
Fluorescently labeled microparticles are useful as standards in flow cytometry, confocal laser scanning microscopy, and with light scattering instruments..
Collagen in Gene Delivery Applications
Collagen-based delivery systems effectively deliver a range of viral and non-viral gene carriers by providing spatiotemporal control over delivery and reducing degradation rates and immune responses.
Reversible Addition Fragmentation Chain Transfer (RAFT) Polymerization
RAFT (Reversible Addition Fragmentation chain Transfer) polymerization is a reversible deactivation radical polymerization (RDRP) and one of the more versatile methods for providing living characteristics to radical polymerization.
Designing Temperature and pH Sensitive NIPAM Based Polymers
Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.
NanoFabTx™: A ready-to-use Microfluidic Platform for mRNA Vaccine Formulation
Knappett, Gray and researcher introduce NanoFabTx™: A ready-to-use microfluidic platform for mRNA vaccine formulation. NanoFabTx™ reagent and microfluidic device kits provide a ready-to-use platform to screen multiple formulations, and ultimately synthesize mRNA or drug-encapsulated liposomes for preclinical assessments.
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