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Merck
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TBX21

T-box 21

别名:
T-PET, T-bet, TBET, TBLYM
物种:
UniProtKB ID:
基因ID:
  • Human(30009) Summary: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
  • Mouse(57765) T-box 21
  • Rat(303496) T-box 21
  • dog(491044) T-box 21
  • sheep(101118711) T-box 21
  • domestic guinea pig(100722972) T-box 21
  • domestic cat(101097604) T-box 21
  • Zebrafish(797797) T-box 21
  • naked mole-rat(101696563) T-box 21
  • cow(538933) T-box 21
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