TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
别名:
CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR
物种:
Human TNFRSF1B (7133), Mouse Tnfrsf1b (21938), Rat Tnfrsf1b (156767), sheep TNFRSF1B (100240715), domestic cat TNFRSF1B (101080392), naked mole-rat Tnfrsf1b (101712824), cow TNFRSF1B (338033), dog TNFRSF1B (487437), Zebrafish tnfrsf1b (100037357), chicken TNFRSF1B (395083)
UniProtKB ID:
基因ID:
- Human(7133) Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
- Mouse(21938) tumor necrosis factor receptor superfamily, member 1b
- Rat(156767) tumor necrosis factor receptor superfamily, member 1b
- sheep(100240715) tumor necrosis factor receptor superfamily, member 1B
- domestic cat(101080392) tumor necrosis factor receptor superfamily, member 1B
- naked mole-rat(101712824) tumor necrosis factor receptor superfamily, member 1B
- cow(338033) tumor necrosis factor receptor superfamily, member 1B
- dog(487437) tumor necrosis factor receptor superfamily, member 1B
- Zebrafish(100037357) tumor necrosis factor receptor superfamily, member 1B
- chicken(395083) tumor necrosis factor receptor superfamily, member 1B
- domestic guinea pig(100723273) tumor necrosis factor receptor superfamily, member 1B
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