252999
尼亚酰铵
95%
别名:
N-异烟酰-N′-[β-(N-苄基甲酰氨基)乙基]肼, N-苄基-β-(异烟肼)丙酰胺, 吡啶-4-甲酰 2-[2-(苄基氨基甲酰)乙基]酰肼
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关于此项目
经验公式（希尔记法）:
C16H18N4O2
化学文摘社编号:
分子量:
298.34
EC Number:
200-079-3
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
492941
MDL number:
Assay:
95%
InChI key
NOIIUHRQUVNIDD-UHFFFAOYSA-N
InChI
1S/C16H18N4O2/c21-15(18-12-13-4-2-1-3-5-13)8-11-19-20-16(22)14-6-9-17-10-7-14/h1-7,9-10,19H,8,11-12H2,(H,18,21)(H,20,22)
SMILES string
O=C(CCNNC(=O)c1ccncc1)NCc2ccccc2
assay
95%
mp
152-154 °C (lit.)
solubility
methanol: soluble 10 mg/mL, clear, colorless to faintly yellow
functional group
amide, amine, hydrazide, phenyl
Gene Information
human ... MAOA(4128), MAOB(4129)
General description
Nialamide is an antidepressant drug and its effect on β-adrenergic receptor-adenylate cyclase system of rat pineal gland has been studied. Antidepressant action of the combination of nialamide and 5-hydroxytryptophan has been evaluated.
Biochem/physiol Actions
非选择性 MAO-A/B 抑制剂。
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
J J Aliño et al.
International pharmacopsychiatry, 11(1), 8-15 (1976-01-01)
Through a controlled double-blind study in 30 hospitalized patients affected with endogenous depression, the antidepressant action of the combination of nialamide+l-5-HTP has been evaluated and compared with a control group which only received nialamide (+ placebo). The patients treated with
P J Whelan et al.
Journal of neurophysiology, 78(3), 1643-1650 (1997-10-06)
Previous studies have shown that stimulation of group 'I' afferents from ankle extensor muscles can prolong the cycle period in decerebrate walking cats and that the magnitude of these effects can be altered after chronic axotomy of the lateral-gastrocnemius/soleus (LGS)
Subsensitivity of the beta-adrenergic receptor-linked adenylate cyclase system of rat pineal gland following repeated treatment with desmethylimipramine and nialamide.
J A Moyer et al.
Molecular pharmacology, 19(2), 187-193 (1981-03-01)
F Datiche et al.
Brain research, 671(1), 27-37 (1995-02-06)
Retrograde axonal transport of the cholera toxin B subunit (CTb) was combined with 5-HT immunohistochemistry to determine the origin of the serotonergic innervation of the piriform cortex (PC) in the rat. After iontophoretic CTb injections in the PC, a substantial
C F Meehan et al.
The Journal of physiology, 590(2), 289-300 (2011-11-23)
Recently, transgenic mice have been created with mutations affecting the components of the mammalian spinal central pattern generator (CPG) for locomotion; however, it has currently only been possible to evoke fictive locomotion in mice, using neonatal in vitro preparations. Here, we demonstrate
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