252999
尼亚酰铵
95%
别名:
N-异烟酰-N′-[β-(N-苄基甲酰氨基)乙基]肼, N-苄基-β-(异烟肼)丙酰胺, 吡啶-4-甲酰 2-[2-(苄基氨基甲酰)乙基]酰肼
方案
95%
mp
152-154 °C (lit.)
溶解性
methanol: soluble 10 mg/mL, clear, colorless to faintly yellow
官能团
amide
amine
hydrazide
phenyl
SMILES字符串
O=C(CCNNC(=O)c1ccncc1)NCc2ccccc2
InChI
1S/C16H18N4O2/c21-15(18-12-13-4-2-1-3-5-13)8-11-19-20-16(22)14-6-9-17-10-7-14/h1-7,9-10,19H,8,11-12H2,(H,18,21)(H,20,22)
InChI key
NOIIUHRQUVNIDD-UHFFFAOYSA-N
基因信息
human ... MAOA(4128), MAOB(4129)
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一般描述
Nialamide is an antidepressant drug and its effect on β-adrenergic receptor-adenylate cyclase system of rat pineal gland has been studied. Antidepressant action of the combination of nialamide and 5-hydroxytryptophan has been evaluated.
生化/生理作用
非选择性 MAO-A/B 抑制剂。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
T Karhula et al.
Neuroscience letters, 194(1-2), 85-88 (1995-07-14)
Localization of 5-hydroxytryptamine immunoreactivity was studied in the rat coeliac-superior mesenteric ganglion complex and in the porcine superior and inferior mesenteric ganglia by the indirect immunofluorescence technique. In normal rats, only 5-hydroxytryptamine immunoreactive SIF cells were seen in the coeliac-superior
Jason A Nieuwsma et al.
Annals of internal medicine, 167(10), 725-735 (2017-11-14)
Patients who have had an acute coronary syndrome (ACS) event have an increased risk for depression. To evaluate the diagnostic accuracy of depression screening instruments and to compare safety and effectiveness of depression treatments in adults within 3 months of
[Modulation of transcranial electroanalgesia by effecting the serotoninergic system of the brain].
A B Savchenko et al.
Doklady Akademii nauk, 347(2), 275-277 (1996-03-01)
H Leblond et al.
The Journal of physiology, 525 Pt 1, 225-240 (2000-05-16)
Intracellular recording of lumbosacral motoneurones in the decerebrate and partially spinalized cat injected with nialamide and L-dihydroxyphenylalanine (l-DOPA) was used to investigate the interneuronal convergence of two bulbospinal pathways and of the segmental pathways involved with the generation of extensor
E D Schomburg et al.
The Journal of physiology, 536(Pt 2), 605-613 (2001-10-16)
1. Nociceptive reflex pathways to foot extensors were investigated with particular attention given to those not following a flexor reflex (FRA) or withdrawal pattern. 2. In anaemically decapitated, high spinal paralysed cats nociceptive afferents of the foot pad were activated
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