253359
4-马来酰亚胺-四甲基哌啶氧化物
for ESR-spectroscopy
别名:
4-马来酰亚胺-2,2,6,6-四甲基-1-氧化哌啶，自由基
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关于此项目
经验公式（希尔记法）:
C13H19N2O3
化学文摘社编号:
分子量:
251.30
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
Form:
solid
InChI
1S/C13H19N2O3/c1-12(2)7-9(8-13(3,4)15(12)18)14-10(16)5-6-11(14)17/h5-6,9H,7-8H2,1-4H3
SMILES string
CC1(C)CC(CC(C)(C)N1[O])N2C(=O)C=CC2=O
InChI key
CMNDHIFMYRPBGH-UHFFFAOYSA-N
description
free radical
form
solid
mp
91-94 °C (lit.)
functional group
imide, maleimide
storage temp.
2-8°C
General description
4-马来酰亚胺-四甲基哌啶氧化物(4-Maleimido-TEMPO)，水溶性氮氧自由基，常用作自旋探针。据报道，其1mM浓度可抑制CHO细胞存活。广泛用作EPR（电子顺磁共振）研究的马来酰亚胺自旋探针。
Application
4-马来酰亚胺-TEMPO（4-马来酰亚胺-四甲基哌啶氧自由基）已作为电子顺磁共振光谱法(EPR)自旋探针，研究胆盐对大鼠完整线粒体膜的影响。也可作为自旋探针标记红细胞膜，通过EPR光谱技术研究槲皮素和红细胞蛋白的相互作用。
Biochem/physiol Actions
用于研究脑突触体膜流动性、红细胞内微粘度和人高密度脂蛋白的自旋标记物。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Fantao Meng et al.
Artificial cells, nanomedicine, and biotechnology, 47(1), 73-82 (2019-01-22)
Compromised microcirculation and endothelial dysfunction are hallmarks of sickle cell disease (SCD). EAF PEG Haemoglobin (Hb) and EAF PEG Albumin (Alb) represent a novel class of semisynthetic colloidal supra plasma expanders that improve microcirculation. The therapeutic activity of supra plasma
Bozena Pawlikowska-Pawlega et al.
Biochemical pharmacology, 66(4), 605-612 (2003-08-09)
Quercetin is a naturally occurring flavonoid that exerts multiple pharmacological effects. In our previous study, we showed that quercetin greatly affects the lipid membrane. In this report, a study of quercetin on human erythrocyte membrane has been performed to determine
Q Garrett et al.
Biomaterials, 20(14), 1345-1356 (1999-07-14)
Human serum albumin (HSA) was specifically spin labelled with 4-maleimido-tempo (MSL) at its cysteine 34 residue (HSA-MSL). The irreversible adsorption of HSA-MSL to hydrogel contact lenses (etafilcon A, tefilcon and vifilcon A) was investigated using electron spin resonance (ESR) spectroscopy.
Kelly Souza Fernandes et al.
Biochimica et biophysica acta, 1859(1), 1-9 (2016-10-27)
In this study, we combined electron paramagnetic resonance (EPR) spectroscopy with an analysis of biophysical cellular parameters to study the mechanisms underlying the in vitro anti-leishmanial activity of miltefosine (MT). A thiol-specific spin label attached to membrane-bound proteins of Leishmania
K Hensley et al.
Biochimica et biophysica acta, 1270(2-3), 203-206 (1995-04-24)
We have applied the technique of electron paramagnetic resonance (EPR) protein-specific spin labeling to the study of membrane protein alterations occurring during age and exposure to isobaric hyperoxia. Cortical synaptosomes and erythrocyte membranes (ghosts) were isolated from young rodents (Fisher
商品
TEMPO（2,2,6,6-四甲基哌啶氧基或2,2,6,6-四甲基哌啶1-氧基）及其衍生物在有机氧化反应催化剂中可以作为稳定的硝酰基使用。TEMPO由Lebedev和Kazarnovskii于1960年发现，其具有的稳定自由基性质得益于其庞大的取代基团阻碍了自由基与其他分子之间发生反应。
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