253359
4-马来酰亚胺-四甲基哌啶氧化物
for ESR-spectroscopy
别名:
4-马来酰亚胺-2,2,6,6-四甲基-1-氧化哌啶，自由基
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关于此项目
经验公式（希尔记法）:
C13H19N2O3
化学文摘社编号:
分子量:
251.30
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
Form:
solid
InChI
1S/C13H19N2O3/c1-12(2)7-9(8-13(3,4)15(12)18)14-10(16)5-6-11(14)17/h5-6,9H,7-8H2,1-4H3
SMILES string
CC1(C)CC(CC(C)(C)N1[O])N2C(=O)C=CC2=O
InChI key
CMNDHIFMYRPBGH-UHFFFAOYSA-N
description
free radical
form
solid
mp
91-94 °C (lit.)
functional group
imide, maleimide
storage temp.
2-8°C
General description
4-马来酰亚胺-四甲基哌啶氧化物(4-Maleimido-TEMPO)，水溶性氮氧自由基，常用作自旋探针。据报道，其1mM浓度可抑制CHO细胞存活。广泛用作EPR（电子顺磁共振）研究的马来酰亚胺自旋探针。
Application
4-马来酰亚胺-TEMPO（4-马来酰亚胺-四甲基哌啶氧自由基）已作为电子顺磁共振光谱法(EPR)自旋探针，研究胆盐对大鼠完整线粒体膜的影响。也可作为自旋探针标记红细胞膜，通过EPR光谱技术研究槲皮素和红细胞蛋白的相互作用。
Biochem/physiol Actions
用于研究脑突触体膜流动性、红细胞内微粘度和人高密度脂蛋白的自旋标记物。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
S Güldütuna et al.
Biochimica et biophysica acta, 1453(3), 396-406 (1999-04-02)
Intact mitochondria were incubated with and without calcium in solutions of chenodeoxycholate, ursodeoxycholate, or their conjugates. Glutamate dehydrogenase, protein and phospholipid release were measured. Alterations in membrane and organelle structure were investigated by electron paramagnetic resonance spectroscopy. Chenodeoxycholate enhanced enzyme
I N Gorshkova et al.
Biochimica et biophysica acta, 1300(2), 103-113 (1996-04-19)
Human low and high density lipoproteins (LDL and HDL, respectively) were treated with porcine pancreatic phospholipase A2 (PLA2) in the presence of albumin resulting in hydrolysis of 40-84% of the lipoproteins phospholipids. The resulting PLA2-treated LDL and HDL and concurrent
D A Butterfield et al.
Methods in enzymology, 309, 746-768 (1999-10-03)
Given the increasing evidence of oxidative stress in AD brain and studies from different perspectives that appear to show a converging, central role for A beta in the pathogenesis and etiology of AD, insight into A beta-associated free radical oxidative
E G Ankel et al.
Life sciences, 40(5), 495-498 (1987-02-02)
Since nitroxide radical spin probes are used frequently to test biophysical properties of cells, their use should be restricted to conditions that do not perturb normal cell growth and viability. Eight commonly used nitroxide radical spin probes have been tested
R Subramaniam et al.
Journal of neurochemistry, 69(3), 1161-1169 (1997-09-01)
Alzheimer's disease (AD) is widely held to be a disorder associated with oxidative stress due, in part, to the membrane action of amyloid beta-peptide (A beta). A beta-associated free radicals cause lipid peroxidation, a major product of which is 4-hydroxy-2-trans-nonenal
商品
TEMPO（2,2,6,6-四甲基哌啶氧基或2,2,6,6-四甲基哌啶1-氧基）及其衍生物在有机氧化反应催化剂中可以作为稳定的硝酰基使用。TEMPO由Lebedev和Kazarnovskii于1960年发现，其具有的稳定自由基性质得益于其庞大的取代基团阻碍了自由基与其他分子之间发生反应。
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