S154
墨蝶呤
solid
别名:
S-(-)-2-氨基-7,8-二氢-6-(2-羟基-1-氧代丙基)-4(1H)-蝶啶酮, L-Sepiapterin
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关于此项目
经验公式（希尔记法）:
C9H11N5O3
化学文摘社编号:
分子量:
237.22
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
Form:
solid
InChI key
VPVOXUSPXFPWBN-VKHMYHEASA-N
SMILES string
C[C@H](O)C(=O)C1=NC2=C(NC1)NC(N)=NC2=O
InChI
1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,15H,2H2,1H3,(H4,10,11,13,14,17)/t3-/m0/s1
form
solid
color
yellow
solubility
DMSO: 27 mg/mL, 0.1 M NaOH: 9.8 mg/mL
εmax
6170 at 409 nm in 0.1 M HCl, 7410 at 271 nm in 0.1 M HCl at 1%
storage temp.
−20°C
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
General description
墨蝶呤是一种蝶啶衍生物，是四氢生物蝶呤（BH4）的一种稳定前体。它是在黑腹果蝇和柠檬家蚕突变体（家蚕）的棕褐色突变体中发现的一种黄色色素。
Application
墨蝶蛉可用于诱导双链DNA中的序列特异性光损伤。
Biochem/physiol Actions
一氧化氮合成酶辅因子；细胞内转化为四氢-生物蝶呤，刺激一氧化氮的生成。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
R Lelchuk et al.
The Journal of pharmacology and experimental therapeutics, 262(3), 1220-1224 (1992-09-01)
Human megakaryoblastic cells (Meg-01) were found to possess constitutive and express inducible nitric oxide (NO) synthase activities. The constitutive NO synthase was Ca+(+)- and NADPH-dependent, as is the NO synthase found previously in human platelets. Stimulation of Meg-01 cells by
Aidamalia Vargas-Lowman et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(38), 19046-19054 (2019-09-06)
Naturalists have been fascinated for centuries by animal colors and color patterns. While widely studied at the adult stage, we know little about color patterns in the embryo. Here, we study a trait consisting of coloration that is specific to
Isolation, purification, and identification of an important pigment, sepiapterin, from integument of the lemon mutant of the silkworm, Bombyx mori."
JunShan G, et al.
Journal of Insect Science, 13(118) (2013)
Matthieu Legrand et al.
Journal of cardiovascular pharmacology, 58(2), 192-198 (2011-05-13)
Acute kidney injury (AKI) can occur after aortic clamping due to microvascular dysfunction leading to renal hypoxia. In this rat study, we have tested the hypothesis that the administration of the precursor of the nitric oxide synthase essential cofactor tetrahydrobiopterin
Photoinduced hydroxylation of deoxyguanosine in DNA by pterins: sequence specificity and mechanism.
Ito K and Kawanishi S
Biochemistry, 36(7), 1774-1781 (1997)
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