S154
墨蝶呤
solid
别名:
S-(-)-2-氨基-7,8-二氢-6-(2-羟基-1-氧代丙基)-4(1H)-蝶啶酮, L-Sepiapterin
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关于此项目
经验公式（希尔记法）:
C9H11N5O3
化学文摘社编号:
分子量:
237.22
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
Form:
solid
form
solid
color
yellow
solubility
DMSO: 27 mg/mL, 0.1 M NaOH: 9.8 mg/mL
εmax
6170 at 409 nm in 0.1 M HCl, 7410 at 271 nm in 0.1 M HCl at 1%
storage temp.
−20°C
SMILES string
C[C@H](O)C(=O)C1=NC2=C(NC1)NC(N)=NC2=O
InChI
1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,15H,2H2,1H3,(H4,10,11,13,14,17)/t3-/m0/s1
InChI key
VPVOXUSPXFPWBN-VKHMYHEASA-N
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
General description
墨蝶呤是一种蝶啶衍生物，是四氢生物蝶呤（BH4）的一种稳定前体。它是在黑腹果蝇和柠檬家蚕突变体（家蚕）的棕褐色突变体中发现的一种黄色色素。
Application
墨蝶蛉可用于诱导双链DNA中的序列特异性光损伤。
Biochem/physiol Actions
一氧化氮合成酶辅因子；细胞内转化为四氢-生物蝶呤，刺激一氧化氮的生成。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Soo Hyeon Kim et al.
Archives of pharmacal research, 34(9), 1571-1577 (2011-10-07)
Tetrahydrobiopterin (BH(4)) has been known to be an essential cofactor for the activities of nitric oxide (NO) synthase and aromatic amino acid hydroxylases, which are involved in physiological and pathological processes. In the present study, we report that sepiapterin, the
S S Gross et al.
The Journal of biological chemistry, 267(36), 25722-25729 (1992-12-25)
Nitric oxide (NO) synthesis is induced in vascular smooth muscle cells by lipopolysaccharide (LPS) where it appears to mediate a variety of vascular dysfunctions. In some cell types tetrahydrobiopterin (BH4) synthesis has also been found to be induced by cytokines.
Photoinduced hydroxylation of deoxyguanosine in DNA by pterins: sequence specificity and mechanism.
Ito K and Kawanishi S
Biochemistry, 36(7), 1774-1781 (1997)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S154-5MG | 04061832992280 |
| S154-25MG | 04061832992273 |