推荐产品
产品名称
羟甲香豆素 钠盐, ≥98% (HPLC), crystalline
质量水平
方案
≥98% (HPLC)
表单
crystalline
颜色
yellow
溶解性
water: 50 mg/mL
SMILES字符串
[Na+].CC1=CC(=O)Oc2cc([O-])ccc12
InChI
1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
InChI key
JGMQHDNPUCPRQE-UHFFFAOYSA-M
一般描述
4-甲基伞形酮（4-MU）是一种香豆素衍生物。
应用
4-甲基伞形酮钠盐已用于：
- 作为底物，分析其在人体肝脏中葡萄糖醛酸化的酶动力学
- 作为定量酶底物作用释放的游离 4-甲基伞形酮的标准品
- 抑制透明质酸（HA）生成的细胞内存活试验及其对卵巢癌症化疗耐药性的影响
生化/生理作用
4-甲基伞形酮（4-MU）作为透明质酸（HA）合成阻断剂。它具有抗炎、抗纤维生成和抗肿瘤的特性。4-甲基伞形酮用于治疗胆汁痉挛，也可能对非酒精性脂肪性肝炎（NASH）、炎症、肝细胞损伤和纤维化反应有益。已知 4-甲基伞形酮被人类肝脏的大多数尿苷 5ฺ-二磷酸葡萄糖醛酸基转移酶（UGT）异构体葡萄糖醛酸化。这使其成为检测整个肝脏 UGT 活性的有效探针底物。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Gale E Smith et al.
Virology, 509, 90-97 (2017-06-19)
Avian influenza A (H5N1) viruses represent a growing threat for an influenza pandemic. The presence of widespread avian influenza virus infections further emphasizes the need for vaccine strategies for control of pre-pandemic H5N1 and other avian influenza subtypes. Influenza neuraminidase
Ai-Sheng Xiong et al.
PloS one, 6(11), e26773-e26773 (2011-11-19)
A β-glucuronidase variant, GUS-TR3337, that was obtained by directed evolution exhibited higher thermostability than the wild-type enzyme, GUS-WT. In this study, the utility of GUS-TR337 as an improved reporter was evaluated. The corresponding gus-tr3337 and gus-wt genes were independently cloned
Matías A Pibuel et al.
Glycobiology, 31(1), 29-43 (2020-05-31)
Glioblastoma (GBM), the most frequent primary tumor of the central nervous system, has a median survival of 14.6 months. 4-Methylumbelliferone (4MU) is a coumarin derivative widely used as a hyaluronan synthesis inhibitor with proven antitumor activity and without toxic effects reported.
Peter Pushko et al.
Virology, 501, 176-182 (2016-12-10)
Avian influenza (AI) viruses circulating in wild birds pose a serious threat to public health. Human and veterinary vaccines against AI subtypes are needed. Here we prepared triple-subtype VLPs that co-localized H5, H7 and H9 antigens derived from H5N1, H7N3
Matías A Pibuel et al.
Glycobiology, 31(1), 29-43 (2020-05-31)
Glioblastoma (GBM), the most frequent primary tumor of the central nervous system, has a median survival of 14.6 months. 4-Methylumbelliferone (4MU) is a coumarin derivative widely used as a hyaluronan synthesis inhibitor with proven antitumor activity and without toxic effects reported.
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