12255
1,2-苯并异噁唑
≥95.0%
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关于此项目
经验公式（希尔记法）:
C7H5NO
化学文摘社编号:
分子量:
119.12
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
205-983-1
Beilstein/REAXYS Number:
2154
MDL number:
产品名称
1,2-苯并异噁唑, ≥95.0%
InChI key
KTZQTRPPVKQPFO-UHFFFAOYSA-N
InChI
1S/C7H5NO/c1-2-4-7-6(3-1)5-8-9-7/h1-5H
SMILES string
c1ccc2oncc2c1
assay
≥95.0%
refractive index
n20/D 1.561 (lit.)
n20/D 1.563
bp
90-92 °C/15 mmHg (lit.)
density
1.174 g/mL at 25 °C (lit.)
storage temp.
2-8°C
Quality Level
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General description
1,2-Benzisoxazole derivative zonisamide is a novel antiepileptic drug and is effective for the treatment of partial seizures. 1,2-Benzisoxazole is a potential substrates of rabbit liver aldehyde oxidase.
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
186.8 °F - closed cup
flash_point_c
86 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
D H Peters et al.
Drugs, 45(5), 760-787 (1993-05-01)
Zonisamide is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug. It has shown activity in various animal models of epilepsy, and although a detailed mode of action awaits clarification
W Gristwood et al.
Xenobiotica; the fate of foreign compounds in biological systems, 18(8), 949-954 (1988-08-01)
1. Twelve oxygen and sulphur azaheterocycles were studied as potential substrates of rabbit liver aldehyde oxidase. Only benzoxazole and 1,2-benzisoxazole were found to be substrates. 2. Nine of the compounds inhibited the oxidation of quinazoline by aldehyde oxidase and in
Nan-Sook Hong et al.
Nature communications, 9(1), 3900-3900 (2018-09-27)
Developments in computational chemistry, bioinformatics, and laboratory evolution have facilitated the de novo design and catalytic optimization of enzymes. Besides creating useful catalysts, the generation and iterative improvement of designed enzymes can provide valuable insight into the interplay between the
Avneet Kaur et al.
Archiv der Pharmazie, 351(6), e1800008-e1800008 (2018-05-10)
A series of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives (3am) was synthesized and evaluated for their in vitro inhibitory activity against COX-1 and COX-2. The compounds with considerable in vitro activity (IC50 < 1 μM) were evaluated in vivo for their anti-inflammatory potential by the carrageenan-induced
Min Bao et al.
International journal of biological macromolecules, 137, 537-544 (2019-06-25)
Studies on endo-inulinases from yeast are scarce, compared to those from other microbial sources. In this study, a novel endo-inulinase from Lipomyces starkeyi NRRL Y-11557 was identified, expressed in its soluble form, and characterized its physicochemically properties, together with its
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