123323
喹唑啉
99%
别名:
1,3-苯并二嗪, 苯并嘧啶
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关于此项目
经验公式（希尔记法）:
C8H6N2
化学文摘社编号:
分子量:
130.15
EC Number:
205-965-3
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
Beilstein/REAXYS Number:
109370
MDL number:
Assay:
99%
Form:
solid
InChI key
JWVCLYRUEFBMGU-UHFFFAOYSA-N
InChI
1S/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H
SMILES string
c1ccc2ncncc2c1
assay
99%
form
solid
bp
243 °C (lit.)
Quality Level
solubility
H2O: freely soluble, organic solvents: soluble
General description
Quinazolines has applications in medicinal chemistry due to their antibacterial, antifungal, anticonvulsant, anti-inflammatory and antitumor activities. It is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.
Application
Quinazoline was used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods.
Biochem/physiol Actions
Genotoxicity of quinazoline was established by bacterial SOS Chromotest (Escherichia Coli).
存储类别
11 - Combustible Solids
flash_point_f
222.8 °F - closed cup
flash_point_c
106 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
Reddy Amala et al.
BioImpacts : BI, 11(1), 15-22 (2021-01-21)
Introduction: Inflammation is the primary response caused due to harmful stimuli which are followed by the increased draining of plasma and immune cells from the body into the site of the injured tissue. A signaling cascade of growth factors and
Polarographic and voltammetric determination of quinazoline-the structural unit of anticancer drugs.
Hladikova J, et al.
Sensing in Electroanalysis, 3, 165-175 (2008)
Elham Bagheri et al.
Current pharmaceutical design, 24(13), 1395-1404 (2018-02-01)
Quinazoline is an aromatic bicyclic compound exhibiting several pharmaceutical and biological activities. This study was conducted to investigate the potential wound healing properties of Synthetic Quinazoline Compound (SQC) on experimental rats. The toxicity of SQC was determined by MTT cell
Hamdoon A Mohammed
Medicinal chemistry (Shariqah (United Arab Emirates)), 16(8), 1044-1057 (2020-02-25)
Suaeda is a halophytic genus belonging to the Amaranthaceae family and can survive in the high salted marsh areas of the world. Suaeda plants can biosynthesize natural substances with powerful antioxidant activity and are considered as a renewable source of
Kunal Nepali et al.
European journal of medicinal chemistry, 196, 112291-112291 (2020-04-24)
This study reports the design, synthesis and evaluation of a series of histone deacetylase (HDAC) inhibitors containing purine/purine isoster as a capping group and an N-(2-aminophenyl)-benzamide unit. In vitro cytotoxicity studies reveal that benzamide 14 suppressed the growth of triple-negative breast
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