127272
1-金刚烷乙酸
98%
别名:
1-Adamantylacetic acid
质量水平
方案
98%
表单
chunks
mp
134-137 °C (lit.)
官能团
carboxylic acid
SMILES字符串
OC(=O)CC12C[C@H]3C[C@H](C[C@H](C3)C1)C2
InChI
1S/C12H18O2/c13-11(14)7-12-4-8-1-9(5-12)3-10(2-8)6-12/h8-10H,1-7H2,(H,13,14)/t8-,9+,10-,12-
InChI key
AOTQGWFNFTVXNQ-GOCCLTDMSA-N
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应用
1-金刚烷乙酸被用作酰化剂，以确定缓激肽 (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) 的 10 个新类似物的药理学特征，这些类似物在分子的 N 端部分发生了修饰 。
生化/生理作用
1-金刚烷乙酸是 大肠埃希菌 K12（菌株 JP 232）分支酸变位酶预苯酸脱氢酶 (EC 1.3.1.12) 的抑制剂 。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
G D Smith et al.
The Biochemical journal, 165(1), 121-126 (1977-07-01)
Several derivatives of phenylalanine and tyrosine were prepared and tested for inhibition of chorismate mutase-prephenate dehydrogenase (EC 1.3.1.12) from Escherichia coli K12 (strain JP 232). The best inhibitors were N-toluene-p-sulphonyl-L-phenylalanine, N-benzenesulphonyl-L-phenylalanine and N-benzloxycarbonyl-L-phenylalanine. Consequently two compounds, N-toluene-sulphonyl-L-p-aminophenylalanine and N-p-aminobenzenesulphonyl-L-phenylalanine, were
Joshua E Mealy et al.
Advanced materials (Deerfield Beach, Fla.), 30(20), e1705912-e1705912 (2018-03-31)
Injectable hydrogels are useful for numerous biomedical applications, such as to introduce therapeutics into tissues or for 3D printing. To expand the complexity of available injectable hydrogels, shear-thinning and self-healing granular hydrogels are developed from microgels that interact via guest-host
Xue Li et al.
ChemMedChem, 15(3), 274-283 (2019-11-26)
Nanomedicine recently emerged as a novel strategy to improve the performance of radiotherapy. Herein we report the first application of radioenhancers made of nanoscale metal-organic frameworks (nanoMOFs), loaded with gemcitabine monophosphate (Gem-MP), a radiosensitizing anticancer drug. Iron trimesate nanoMOFs possess
Alexander Trifonov et al.
ACS nano, 13(8), 8630-8638 (2019-07-17)
Through a careful chemical and bioelectronic design we have created a system that uses self-assembly of enzyme-nanoparticle hybrids to yield bioelectrocatalytic functionality and to enable the harnessing of electrical power from biomass. Here we show that mixed populations of hybrids
Juan Manuel Gutierrez-Villagomez et al.
Talanta, 162, 440-452 (2016-11-14)
In this study, we report for the first time the efficiency of pentafluorobenzyl bromide (PFBBr) for naphthenic acid (NA) mixtures derivatization, and the comparison in the optimal conditions to the most common NAs derivatization reagents, BF
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