128430
L-谷氨酸
99%
别名:
(S)-2-氨基戊二酸, Glu
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线性分子式:
HO2CCH2CH2CH(NH2)CO2H
化学文摘社编号:
分子量:
147.13
EC Number:
200-293-7
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
1723801
InChI
1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChI key
WHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES string
N[C@@H](CCC(O)=O)C(O)=O
assay
99%
optical activity
[α]20/D +31.5°, c = 2 in 5 M HCl
mp
205 °C (dec.) (lit.)
solubility
H2O: soluble 140 gm/l at 100 degrees c, H2O: soluble 21.86 gm/l at 50 degrees c, H2O: soluble 55.32 gm/l at 75 degrees c, H2O: soluble 8.64 gm/l at 25 degrees c, hydrochloric acid: soluble 10% in 1 N, clear, colorless
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Application
L-Glutamic acid has been used as a supplement for selection medium, SORB-TOP-His.
Biochem/physiol Actions
一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。
L-Glutamic acid along with l-Lysine is used for preparation of Bifunctional DTPA-like Ligands. L-glutamic acid can stimulate the spontaneous release of [3H] dopamine ( [3H] DA).
存储类别
11 - Combustible Solids
wgk
WGK 1
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
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Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices.
M F Giorguieff et al.
Neuroscience letters, 6(1), 73-77 (1977-10-01)
Luigi F Agnati et al.
Pharmacological reviews, 55(3), 509-550 (2003-07-19)
The molecular basis for the known intramembrane receptor/receptor interactions among G protein-coupled receptors was postulated to be heteromerization based on receptor subtype-specific interactions between different types of receptor homomers. The discovery of GABAB heterodimers started this field rapidly followed by
Kimberly J Dougherty et al.
Neuron, 80(4), 920-933 (2013-11-26)
Locomotion is controlled by spinal networks that generate rhythm and coordinate left-right and flexor-extensor patterning. Defined populations of spinal interneurons have been linked to patterning circuits; however, neurons comprising the rhythm-generating kernel have remained elusive. Here, we identify an ipsilaterally
Ulrike Pannasch et al.
Nature neuroscience, 17(4), 549-558 (2014-03-04)
Astrocytes play active roles in brain physiology by dynamic interactions with neurons. Connexin 30, one of the two main astroglial gap-junction subunits, is thought to be involved in behavioral and basic cognitive processes. However, the underlying cellular and molecular mechanisms
Nils Muhlert et al.
Journal of neurology, neurosurgery, and psychiatry, 85(8), 833-839 (2014-01-17)
Glutamate is the principal excitatory neurotransmitter and is involved in normal brain function. Cognitive impairment is common in multiple sclerosis (MS), and understanding its mechanisms is crucial for developing effective treatments. We used structural and metabolic brain imaging to test
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