130710
4-氯-DL-苯丙氨酸
99%
别名:
PCP, PCPA
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关于此项目
线性分子式:
ClC6H4CH2CH(NH2)CO2H
化学文摘社编号:
分子量:
199.63
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
231-051-9
MDL number:
InChI key
NIGWMJHCCYYCSF-UHFFFAOYSA-N
InChI
1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
SMILES string
NC(Cc1ccc(Cl)cc1)C(O)=O
assay
99%
mp
>240 °C (dec.) (lit.)
Biochem/physiol Actions
色氨酸羟化酶抑制剂。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral - Skin Sens. 1
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
E Manová et al.
The British journal of dermatology, 171(6), 1368-1374 (2014-08-27)
Octocrylene (OCT) is an ultraviolet (UV) filter used in personal care products (PCPs) to prevent sun-related skin damage. OCT is photostable and has the ability to photostabilize other UV filters, which has recently led to its increased use in PCPs.
Mark J Airhart et al.
Neurotoxicology and teratology, 34(1), 152-160 (2011-09-07)
In this study, p-chlorophenylalanine (pCPA), an inhibitor of tryptophan hydroxylase (the rate limiting enzyme of serotonin synthesis), was used to reduce serotonin (5HT) levels during early development in zebrafish embryos. One day old dechorionated embryos were treated with 25 μM
Alicia Izquierdo et al.
Behavioural brain research, 233(2), 494-499 (2012-06-02)
Aside from the well-known influence of serotonin (5-hydroxytryptamine, 5-HT) on emotional regulation, more recent investigations have revealed the importance of this monoamine in modulating cognition. Parachlorophenylalanine (PCPA) depletes 5-HT by inhibiting tryptophan hydroxylase, the enzyme required for 5-HT synthesis and
Shannon M Steinberg et al.
Cancer immunology research, 2(11), 1044-1050 (2014-09-04)
A growing body of evidence suggests that BRAF inhibitors, in addition to their acute tumor growth-inhibitory effects, can also promote immune responses to melanoma. The present study aimed to define the immunologic basis of BRAF-inhibitor therapy using the Braf/Pten model
Silvina L Diaz et al.
The European journal of neuroscience, 38(5), 2650-2658 (2013-07-12)
Increased adult neurogenesis is a major neurobiological correlate of the beneficial effects of antidepressants. Indeed, selective serotonin (5-HT) re-uptake inhibitors, which increase 5-HT transmission, enhance adult neurogenesis in the dentate gyrus (DG) of the hippocampus. However, the consequences of 5-HT
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