131768
水杨酰苯胺
98%
别名:
2-羟基-N-苯基苯酰胺, 2-羟基苯酰替苯胺, N-苯基水杨酰胺
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线性分子式:
2-(HO)C6H4CONHC6H5
化学文摘社编号:
分子量:
213.23
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
201-727-8
Beilstein/REAXYS Number:
1108135
MDL number:
Assay:
98%
Form:
liquid
InChI key
WKEDVNSFRWHDNR-UHFFFAOYSA-N
InChI
1S/C13H11NO2/c15-12-9-5-4-8-11(12)13(16)14-10-6-2-1-3-7-10/h1-9,15H,(H,14,16)
SMILES string
Oc1ccccc1C(=O)Nc2ccccc2
assay
98%
form
liquid
solubility
alcohol: freely soluble, benzene: freely soluble, chloroform: freely soluble, diethyl ether: freely soluble
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General description
Salicylanilide inhibited mycobacterial isocitrate lyase (ICL) and showed a significant antimycobacterial effect.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Jarmila Vinsova et al.
Molecules (Basel, Switzerland), 12(1), 1-12 (2007-08-19)
A new series of salicylanilide acetates was synthesized and evaluated for their in vitro antifungal and antituberculotic activity. Some of the evaluated compounds possessed comparable or better antifungal activity than a fluconazole standard. All these compounds exhibited very good potential
Ales Imramovsky et al.
Molecules (Basel, Switzerland), 17(9), 10142-10158 (2012-08-28)
A series of twenty-five novel salicylanilide N-alkylcarbamates were investigated as potential acetylcholinesterase inhibitors. The compounds were tested for their ability to inhibit acetylcholinesterase (AChE) from electric eel (Electrophorus electricus L.). Experimental lipophilicity was determined, and the structure-activity relationships are discussed.
Rohit Sharma et al.
Recent patents on inflammation & allergy drug discovery, 7(2), 114-123 (2013-03-20)
Current TB regimen involves a combination of first and second line drugs which target only a small number of core metabolic processes such as deoxyribonucleic acid (DNA)/ ribonucleic acid (RNA) synthesis, cell wall synthesis, and energy metabolism pathways. New classes
Martin Krátký et al.
TheScientificWorldJournal, 2012, 290628-290628 (2012-06-06)
The resistance to antimicrobial agents brings a need of novel antimicrobial agents. We have synthesized and found the in vitro antibacterial activity of salicylanilide esters with benzoic acid (2-(phenylcarbamoyl)phenyl benzoates) in micromolar range. They were evaluated in vitro for the
Jim P Boyce et al.
Bioconjugate chemistry, 19(9), 1775-1784 (2008-09-04)
Salicylanilides were found as selective inhibitors of interleukin-12p40 production in stimulated dendritic cells. The conversion of one of these bioactive salicylanilides into a comparably bioactive, chemically labeled derivative was achieved using a facile and systematic functional group derivatization strategy. This
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