131768
水杨酰苯胺
98%
别名:
2-羟基-N-苯基苯酰胺, 2-羟基苯酰替苯胺, N-苯基水杨酰胺
方案
98%
表单
liquid
mp
136-138 °C (lit.)
溶解性
H2O: slightly soluble
alcohol: freely soluble
benzene: freely soluble
chloroform: freely soluble
diethyl ether: freely soluble
SMILES字符串
Oc1ccccc1C(=O)Nc2ccccc2
InChI
1S/C13H11NO2/c15-12-9-5-4-8-11(12)13(16)14-10-6-2-1-3-7-10/h1-9,15H,(H,14,16)
InChI key
WKEDVNSFRWHDNR-UHFFFAOYSA-N
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一般描述
Salicylanilide inhibited mycobacterial isocitrate lyase (ICL) and showed a significant antimycobacterial effect.
警示用语：
Warning
危险分类
Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Ales Imramovsky et al.
Molecules (Basel, Switzerland), 17(9), 10142-10158 (2012-08-28)
A series of twenty-five novel salicylanilide N-alkylcarbamates were investigated as potential acetylcholinesterase inhibitors. The compounds were tested for their ability to inhibit acetylcholinesterase (AChE) from electric eel (Electrophorus electricus L.). Experimental lipophilicity was determined, and the structure-activity relationships are discussed.
Jim P Boyce et al.
Bioconjugate chemistry, 19(9), 1775-1784 (2008-09-04)
Salicylanilides were found as selective inhibitors of interleukin-12p40 production in stimulated dendritic cells. The conversion of one of these bioactive salicylanilides into a comparably bioactive, chemically labeled derivative was achieved using a facile and systematic functional group derivatization strategy. This
Jarmila Vinsova et al.
Molecules (Basel, Switzerland), 12(1), 1-12 (2007-08-19)
A new series of salicylanilide acetates was synthesized and evaluated for their in vitro antifungal and antituberculotic activity. Some of the evaluated compounds possessed comparable or better antifungal activity than a fluconazole standard. All these compounds exhibited very good potential
Rohit Sharma et al.
Recent patents on inflammation & allergy drug discovery, 7(2), 114-123 (2013-03-20)
Current TB regimen involves a combination of first and second line drugs which target only a small number of core metabolic processes such as deoxyribonucleic acid (DNA)/ ribonucleic acid (RNA) synthesis, cell wall synthesis, and energy metabolism pathways. New classes
Martin Krátký et al.
TheScientificWorldJournal, 2012, 290628-290628 (2012-06-06)
The resistance to antimicrobial agents brings a need of novel antimicrobial agents. We have synthesized and found the in vitro antibacterial activity of salicylanilide esters with benzoic acid (2-(phenylcarbamoyl)phenyl benzoates) in micromolar range. They were evaluated in vitro for the
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