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135712

2-氯-5-硝基苯甲腈

Name: 2-氯-5-硝基苯甲腈
Brand: ALDRICH

99%

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关于此项目

线性分子式:

ClC₆H₃(NO₂)CN

化学文摘社编号:

16588-02-6

分子量:

182.56

NACRES:

NA.22

PubChem Substance ID:

24848218

UNSPSC Code:

12352100

EC Number:

240-643-6

MDL number:

MFCD00007292

Assay:

99%

Form:

powder

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属性

Quality Level

100

assay

99%

form

powder

mp

105-107 °C (lit.)

functional group

chloro, nitrile, nitro

SMILES string

[O-][N+](=O)c1ccc(Cl)c(c1)C#N

InChI

1S/C7H3ClN2O2/c8-7-2-1-6(10(11)12)3-5(7)4-9/h1-3H

InChI key

ZGILLTVEEBNDOB-UHFFFAOYSA-N

说明

General description

2-Chloro-5-nitrobenzonitrile effectively conjugates with rat glutathione S-transferase (GST) isoenzymes and is an alternative model substrate in GST-research.

Application

2-Chloro-5-nitrobenzonitrile was used in online detection of rat glutathione S-transferase P1-specific inhibitors by high-resolution screening technology.

pictograms

GHS07

signalword

Warning

hcodes

H312 + H332,H315,H319,H335

pcodes

P261 - P264 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Enzyme kinetics and substrate selectivities of rat glutathione S-transferase isoenzymes towards a series of new 2-substituted 1-chloro-4-nitrobenzenes.

E M van der Aar et al.

Xenobiotica; the fate of foreign compounds in biological systems, 26(2), 143-155 (1996-02-01)

1. Four different rat glutathione S-transferase (GST) isoenzymes, belonging to three different classes, were examined for their GSH conjugating capacity towards 11 2-substituted 1-chloro-4-nitrobenzene derivatives. Significant differences were found in their enzyme kinetic parameters Km, kcat and kcat/Km. 2. Substrates

Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures.

Jeroen Kool et al.

Journal of biomolecular screening, 12(3), 396-405 (2007-03-24)

A high-resolution screening (HRS) technology is described, which couples 2 parallel enzyme affinity detection (EAD) systems for substrates and inhibitors of rat cytosolic glutathione-S-transferases (cGSTs) and purified human GST P1 to gradient reversed-phase high-performance liquid chromatography (HPLC). The cGSTs and

全球贸易项目编号

货号	GTIN
O6887-1MG	04061826285060
135712-25G	04061832097992
135712-100G	04061832106038