140325
8-羟基-5-硝基喹啉
96%
别名:
5-硝基-8-羟基喹啉
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关于此项目
经验公式（希尔记法）:
C9H6N2O3
化学文摘社编号:
分子量:
190.16
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
223-662-4
MDL number:
Assay:
96%
Form:
powder
产品名称
8-羟基-5-硝基喹啉, 96%
InChI key
RJIWZDNTCBHXAL-UHFFFAOYSA-N
InChI
1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H
SMILES string
Oc1ccc([N+]([O-])=O)c2cccnc12
assay
96%
form
powder
mp
181-183 °C (lit.)
solubility
alcohol: very slightly soluble
diethyl ether: very slightly soluble
hydrochloric acid: freely soluble (hot)
functional group
nitro
Quality Level
Application
8-羟基-5-硝基喹啉用于合成新型CO2可溶性8-羟基喹啉螯合剂。
Biochem/physiol Actions
8-羟基-5-硝基喹啉是一种有效的抗菌剂和抗癌剂。这是治疗革兰氏阴性杆菌所致各种尿路感染的有效药物。
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Highly CO2-soluble 5-Amido-8-hydroxyquinoline Chelating Agents for Extraction of Metals in Sc-CO2.
Chang F, et al.
Bull. Korean Chem. Soc., 29(7), 1327-1327 (2008)
Serena Veschi et al.
Journal of experimental & clinical cancer research : CR, 37(1), 236-236 (2018-09-23)
Pancreatic cancer (PC) is the fourth most common cause of cancer death. Combination therapies with classical chemotherapeutic agents improved treatment of advanced PC at the cost of a relevant toxicity, but the 5-year survival rate remains below 5%. Consequently, new
B Murugasu-Oei et al.
International journal of antimicrobial agents, 18(6), 579-582 (2001-12-12)
The chelating antibiotic nitroxoline (5-nitro-8-hydroxyquinoline) showed a bacteriostatic effect at a concentration of 10 microM for Mycobacterium bovis BCG. At higher concentrations the compound showed moderate cidal activity against growing bacilli. In contrast, its non-nitrated derivative oxine (8-hydroxyquinoline, MIC=2 microM)
Serena Veschi et al.
Journal of enzyme inhibition and medicinal chemistry, 35(1), 1331-1344 (2020-06-27)
Pancreatic cancer (PC) is one of the deadliest carcinomas and in most cases, which are diagnosed with locally advanced or metastatic disease, current therapeutic options are highly unsatisfactory. Based on the anti-proliferative effects shown by nitroxoline, an old urinary antibacterial
C Pelletier et al.
Antimicrobial agents and chemotherapy, 39(3), 707-713 (1995-03-01)
The antibacterial activity of nitroxoline (NIT), an antibiotic used in the treatment of acute or recurrent urinary tract infections caused by Escherichia coli, is decreased in the presence of Mg2+ and Mn2+ but not Ca2+. In order to elucidate the
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