143413
1,3-二氨基胍 单盐酸盐
98%
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关于此项目
线性分子式:
H2NNHC(=NH)NHNH2·HCl
化学文摘社编号:
分子量:
125.56
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
方案
98%
mp
180-182 °C (dec.) (lit.)
溶解性
water: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
SMILES字符串
Cl.NNC(=N)NN
InChI
1S/CH7N5.ClH/c2-1(5-3)6-4;/h3-4H2,(H3,2,5,6);1H
InChI key
HAZRIBSLCUYMQP-UHFFFAOYSA-N
一般描述
1,3-二氨基胍盐酸盐可用于以下缩合反应：
- 与4-異硫氰酸-4-甲基戊烷-2-酮反应生成缩合嘧啶
- 与各种醛和酮反应生成双胍类衍生物
其他说明
含氯化钠
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
D Dvornik et al.
Journal of diabetes and its complications, 10(1), 23-30 (1996-01-01)
Aminoguanidine, nucleophilic hydrazine derivative, has been shown to inhibit diamine oxidase, the formation of advanced glycation endproducts, nitric oxide synthase, and catalase. Prompted by the reports that aminoguanidine also inhibits aldose reductase (AR), we have investigated the effect of aminoguanidine
K Kumari et al.
Diabetes, 40(8), 1079-1084 (1991-08-01)
Mono- and diaminoguanidine inhibited ambient glucose-induced glycosylated end product formation of albumin and collagen 125I-labeled albumin covalent binding in vitro. Diaminoguanidine was a stronger inhibitor than monoaminoguanidine. These compounds also inhibited rat eye lens aldose reductase activity in vitro noncompetitively
Naoyoshi Ishikawa et al.
Kidney international, 63(1), 331-339 (2002-12-11)
Reactive carbonyl compounds (RCOs) present in peritoneal dialysis (PD) fluid have been incriminated in the progressive deterioration of the peritoneal membrane in long-term PD patients. They are initially present in fresh conventional heat-sterilized glucose PD fluid and are supplemented during
K Hasan et al.
European journal of pharmacology, 249(1), 101-106 (1993-11-02)
Aminoguanidine, N,N'-diaminoguanidine, methylguanidine, and 1,1-dimethylguanidine were compared to NG-monomethyl-L-arginine (L-NMMA) for their ability to inhibit nitric oxide (NO) formation by cytokine-inducible and vascular constitutive isoforms of NO synthase. These comparisons were performed by assessing (1) cytokine-induced production of nitrite by
Synthesis of condensed pyrimidines and their evaluation for anti-inflammatory and analgesic activities.
Sondhi SM, et al.
Indian J. Chem. B, 47(1), 136-136 (2008)
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