143413
1,3-二氨基胍 单盐酸盐
98%
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关于此项目
线性分子式:
H2NNHC(=NH)NHNH2·HCl
化学文摘社编号:
分子量:
125.56
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
252-854-0
MDL number:
InChI key
HAZRIBSLCUYMQP-UHFFFAOYSA-N
InChI
1S/CH7N5.ClH/c2-1(5-3)6-4;/h3-4H2,(H3,2,5,6);1H
SMILES string
Cl.NNC(=N)NN
assay
98%
mp
180-182 °C (dec.) (lit.)
solubility
water: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
General description
1,3-二氨基胍盐酸盐可用于以下缩合反应：
- 与4-異硫氰酸-4-甲基戊烷-2-酮反应生成缩合嘧啶
- 与各种醛和酮反应生成双胍类衍生物
Other Notes
含氯化钠
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
K Kumari et al.
Diabetes, 40(8), 1079-1084 (1991-08-01)
Mono- and diaminoguanidine inhibited ambient glucose-induced glycosylated end product formation of albumin and collagen 125I-labeled albumin covalent binding in vitro. Diaminoguanidine was a stronger inhibitor than monoaminoguanidine. These compounds also inhibited rat eye lens aldose reductase activity in vitro noncompetitively
D Dvornik et al.
Journal of diabetes and its complications, 10(1), 23-30 (1996-01-01)
Aminoguanidine, nucleophilic hydrazine derivative, has been shown to inhibit diamine oxidase, the formation of advanced glycation endproducts, nitric oxide synthase, and catalase. Prompted by the reports that aminoguanidine also inhibits aldose reductase (AR), we have investigated the effect of aminoguanidine
Naoyoshi Ishikawa et al.
Kidney international, 63(1), 331-339 (2002-12-11)
Reactive carbonyl compounds (RCOs) present in peritoneal dialysis (PD) fluid have been incriminated in the progressive deterioration of the peritoneal membrane in long-term PD patients. They are initially present in fresh conventional heat-sterilized glucose PD fluid and are supplemented during
Synthesis of biologically active novel bis Schiff bases, bis hydrazone and bis guanidine derivatives.
Sondhi SM, et al.
Indian J. Chem. B, 48(8), 1128-1128 (2009)
Anthony J Lee et al.
Chemical research in toxicology, 18(12), 1927-1933 (2005-12-20)
It is established that aminoguanidine (AG), diaminoguanidine (DAG), and NG-amino-l-arginine (NAA) are metabolism-based inactivators of the three major isoforms of nitric oxide synthase (NOS). In the case of neuronal NOS (nNOS), heme alteration is known to be a major cause
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