方案
98%
mp
113-117 °C (lit.)
官能团
amine
phenyl
SMILES字符串
NC(=S)c1ccccc1
InChI
1S/C7H7NS/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9)
InChI key
QIOZLISABUUKJY-UHFFFAOYSA-N
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应用
硫代苯甲酰胺用于制备酰胺和脒加合物。它也用于合成 4-氧代-4H-亚甲基-3-碳硫代甲酸 N-苯酰胺。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Yakov M Koen et al.
Chemical research in toxicology, 26(4), 564-574 (2013-03-08)
Thioacetamide (TA) has long been known as a hepatotoxicant whose bioactivation requires S-oxidation to thioacetamide S-oxide (TASO) and then to the very reactive S,S-dioxide (TASO2). The latter can tautomerize to form acylating species capable of covalently modifying cellular nucleophiles including
W G Chung et al.
Molecules and cells, 7(6), 738-741 (1998-03-24)
Flavin-containing monooxygenase (FMO), known not to be induced by xenobiotics, has been induced by a polycyclic aromatic hydrocarbon, 3-methylcholanthrene (3MC). We have found a prominent augmentation of hepatic FMO1 both at transcription and translation levels by pretreatment of rats with
A K Naidu et al.
Research communications in chemical pathology and pharmacology, 71(2), 175-188 (1991-02-01)
Earlier this laboratory recognized lipoxygenase catalyzed reactions as a novel pathway for xenobiotic metabolism. To further explore the spectrum of reactions catalyzed by lipoxygenase, sulfoxidation of thiobenzamide was studied. Purified soybean lipoxygenase was found to oxidize thiobenzamide to thiobenzamide sulfoxide
J M Domagala et al.
Drug design and discovery, 15(1), 49-61 (1997-05-01)
Substituted 2,2'-dithiobisbenzamides and 2-benzisothiazolones were prepared and shown to possess low microM activity with high therapeutic indices against HIV-1, HIV-2 and SIV in cell culture. The mechanism of antiviral action was determined to be directed toward the nucleocapsid protein (NCp7)
E Chieli et al.
Archives of toxicology, 64(2), 122-127 (1990-01-01)
The effect of acetone pretreatment (5% in drinking water for 10 days on rat liver metabolism and toxicity of thiobenzamide (TB) was investigated. Hepatic microsomes from acetone-pretreated rats showed a significant increase of TB-S-oxidation rate which, on the basis of
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