方案
97%
表单
liquid
折射率
n20/D 1.4775 (lit.)
沸点
94-95 °C/0.5 mmHg (lit.)
密度
0.944 g/mL at 25 °C (lit.)
官能团
hydroxyl
SMILES字符串
OCCCN1CCCCC1
InChI
1S/C8H17NO/c10-8-4-7-9-5-2-1-3-6-9/h10H,1-8H2
InChI key
PLRXAFVBCHEMGD-UHFFFAOYSA-N
应用
1-Piperidinepropanol was used to prepare isothiourea.
Reactant in:
Mitsunobu reaction of intramolecular nitrile oxide-alkene cycloadditions
Suzuki-coupling
Reactant for synthesis of:
Histamine H3 receptor antagonists
Protein lysine methyltransferase G9a inhibitors
Serotonin-4 receptors antagonists
Checkpoint kinase Chk2 inhibitors
Mitsunobu reaction of intramolecular nitrile oxide-alkene cycloadditions
Suzuki-coupling
Reactant for synthesis of:
Histamine H3 receptor antagonists
Protein lysine methyltransferase G9a inhibitors
Serotonin-4 receptors antagonists
Checkpoint kinase Chk2 inhibitors
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
208.0 °F - closed cup
闪点(°C)
97.8 °C - closed cup
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Shinya Harusawa et al.
Bioorganic & medicinal chemistry letters, 23(23), 6415-6420 (2013-10-22)
S-Alkyl-N-alkylisothiourea compounds containing various cyclic amines were synthesized in the search for novel nonimidazole histamine H3 receptor (H3R) antagonists. Among them, four N-alkyl S-[3-(piperidin-1-yl)propyl]isothioureas 18, 19, 22, and 23 were found to exhibit potent and selective H3R antagonistic activities against
Joseph A McQuail et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(50), 12537-12548 (2016-11-04)
Working memory, the ability to temporarily maintain representational knowledge, is a foundational cognitive process that can become compromised in aging and neuropsychiatric disease. NMDA receptor (NMDAR) activation in prefrontal cortex (PFC) is necessary for the pyramidal neuron activity believed to
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