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Merck
CN

15719

D -甘露醇

meets analytical specification of Ph. Eur., USP, FCC, E421, 98.0-101.5% (calc. to the dried substance, HPLC)

别名:

甘露糖醇

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关于此项目

经验公式（希尔记法）:
C6H14O6
化学文摘社编号:
69-65-8
分子量:
182.17
EC Number:
200-711-8
UNSPSC Code:
12352200
PubChem Substance ID:
22435040
Beilstein/REAXYS Number:
1721898
MDL number:
MFCD00064287

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assay

98-102% (calc. to dried substance), 98.0-101.5% (calc. to the dried substance, HPLC)

optical activity

[α]20/D +23 to +25°, c = 8% in Na2B4O7, [α]25/D +137 to +145

quality

meets analytical specification of Ph. Eur., USP, FCC, E421

impurities

acidity or alcalinity, complies, reducing sugars, complies, related substances, in accordance (HPLC), residual solvents, complies, sorbit (DC), complies, ≤0.007% free acid (as CH3COOH), ≤0.5% water (Karl Fischer)

ign. residue

≤0.1% (as SO4)

loss

≤0.3% loss on drying, 105 °C, 4 h

pH

5-7.5 (20 °C, 10%)

conductivity

20 μS/cm at 20 °C

mp

165-169 °C, 167-170 °C (lit.)

anion traces

chloride (Cl-): ≤50 mg/kg, sulfate (SO42-): ≤100 mg/kg

cation traces

As: ≤1 mg/kg, Cu: ≤10 mg/kg, Ni: ≤1 mg/kg, Zn: ≤10 mg/kg

suitability

complies for appearance of solution, passes test for identity (IR)

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

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Biochem/physiol Actions

一种糖醇类甜味剂。 用于甜味抑制研究。

存储类别

11 - Combustible Solids

ppe

Eyeshields, Gloves, type N95 (US)

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
70440
SZBB1500
SZBA2600
SZBB1500V
SZBA2600V

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To compare a new bronchial provocation test, the mannitol challenge, with cold air and histamine challenges to demonstrate airway hyperresponsiveness (AHR) in patients with difficult-to-diagnose asthma. A prospective study. Thirty-seven consecutive patients with recently diagnosed, steroid-naive, mild, or atypical asthma
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Chest, 124(4), 1341-1349 (2003-10-14)
To compare the sensitivity and validity of mannitol, histamine, and cold air challenges to demonstrate the effect of inhaled corticosteroids (ICS) in asthma. A prospective study. Seventeen patients with recently diagnosed, steroid-naive asthma who fulfilled the diagnostic criteria of Finnish
Diana Bilton et al.
Thorax, 69(12), 1073-1079 (2014-09-24)
Bronchiectasis is characterised by excessive production of mucus and pulmonary exacerbations. Inhaled osmotic agents may enhance mucociliary clearance, but few long-term clinical trials have been conducted. To determine the impact of inhaled mannitol on exacerbation rates in patients with non-cystic
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