176478
3-(4-氟苯甲酰)丙酸
97%
别名:
R 11302, 氟哌啶醇代谢物 III
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关于此项目
线性分子式:
FC6H4COCH2CH2CO2H
化学文摘社编号:
分子量:
196.18
PubChem Substance ID:
eCl@ss:
39040324
UNSPSC Code:
12352100
NACRES:
NA.22
EC Number:
206-679-1
MDL number:
Assay:
97%
Form:
solid
assay
97%
form
solid
mp
100-102 °C (lit.)
SMILES string
OC(=O)CCC(=O)c1ccc(F)cc1
InChI
1S/C10H9FO3/c11-8-3-1-7(2-4-8)9(12)5-6-10(13)14/h1-4H,5-6H2,(H,13,14)
InChI key
WUYWHIAAQYQKPP-UHFFFAOYSA-N
General description
3-(4-Fluorobenzoyl)propionic acid is a metabolite of haloperidol, a dopamine D2 receptor blocker.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
T Tateishi et al.
Life sciences, 67(24), 2913-2920 (2001-01-02)
We studied the biotransformation of haloperidol, bromperidol and their reduced forms by human liver microsomes. Nifedipine oxidation (CYP3A) activity correlated significantly with N-dealkylation rates of haloperidol and bromperidol and oxidation rates of their reduced forms, while neither ethoxyresorufin O-deethylation (CYP1A2)
M Watanabe et al.
Fundamental & clinical pharmacology, 13(3), 337-342 (1999-07-07)
Haloperidol (HP), an antipsychotic drug, is N-dealkylated by cytochrome P450 (CYP) to 4-fluorobenzoylpropionic acid (FBPA). The purpose of this study was to identify whether CYP3A metabolizes HP to FBPA in hepatic microsomes of rats and to investigate whether an inhibitor
G A Digenis et al.
Journal of pharmaceutical sciences, 70(9), 985-989 (1981-09-01)
Tissue distribution studies of [18F]haloperidol and [82Br]bromperidol, two potent neuroleptic drugs, were performed in rats by serial sacrifice. The usefulness of external scintigraphy in obtaining tissue distribution data in large animals is demonstrated by the tissue distribution of [18F]haloperidol in
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 176478-5G | 04061831818970 |