176478
3-(4-氟苯甲酰)丙酸
97%
别名:
R 11302, 氟哌啶醇代谢物 III
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线性分子式:
FC6H4COCH2CH2CO2H
化学文摘社编号:
分子量:
196.18
EC 号:
MDL编号:
UNSPSC代码:
12352100
eCl@ss:
39040324
PubChem化学物质编号:
NACRES:
NA.22
方案
97%
表单
solid
mp
100-102 °C (lit.)
SMILES字符串
OC(=O)CCC(=O)c1ccc(F)cc1
InChI
1S/C10H9FO3/c11-8-3-1-7(2-4-8)9(12)5-6-10(13)14/h1-4H,5-6H2,(H,13,14)
InChI key
WUYWHIAAQYQKPP-UHFFFAOYSA-N
一般描述
3-(4-Fluorobenzoyl)propionic acid is a metabolite of haloperidol, a dopamine D2 receptor blocker.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Sarita Forsback et al.
Synapse (New York, N.Y.), 51(2), 119-127 (2003-11-18)
In order to characterize the sensitivity of an analog of levodopa and a dopamine transporter ligand to detect defects in nigrostriatal function, the uptake of [(18)F]FDOPA and [(18)F]CFT was studied ex vivo in a rat model of Parkinson's disease. The
M Watanabe et al.
Xenobiotica; the fate of foreign compounds in biological systems, 29(8), 839-846 (1999-12-20)
1. The aim was to identify whether CYP3A metabolizes bromperidol (BP), an antipsychotic drug, to form 4-fluorobenzoyl-propionic acid (FBPA) in hepatic microsomes from 8-week-old male Sprague-Dawley rats and to investigate whether an inhibitor or an inducer of CYP3A affects BP
G A Digenis et al.
Journal of pharmaceutical sciences, 70(9), 985-989 (1981-09-01)
Tissue distribution studies of [18F]haloperidol and [82Br]bromperidol, two potent neuroleptic drugs, were performed in rats by serial sacrifice. The usefulness of external scintigraphy in obtaining tissue distribution data in large animals is demonstrated by the tissue distribution of [18F]haloperidol in
Hyeon Soo Kim et al.
Journal of neurochemistry, 99(2), 458-469 (2006-10-13)
Haloperidol, a dopamine D2 receptor blocker, is a classical neuroleptic drug that elicits extrapyramidal symptoms. Its metabolites include 3-(4-fluorobenzoyl) propionic acid (FBPA) and 4-(4-chlorophenyl)-4-piperidinol (CPHP). Until now, the biological significance of these metabolites has remained largely unknown. Here, we report
M Watanabe et al.
Fundamental & clinical pharmacology, 13(3), 337-342 (1999-07-07)
Haloperidol (HP), an antipsychotic drug, is N-dealkylated by cytochrome P450 (CYP) to 4-fluorobenzoylpropionic acid (FBPA). The purpose of this study was to identify whether CYP3A metabolizes HP to FBPA in hepatic microsomes of rats and to investigate whether an inhibitor
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