180823
5-甲基-5-苯基乙内酰脲
99%
别名:
5-Methyl-5-phenylimidazolidine-2,4-dione, NSC 14839
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关于此项目
经验公式（希尔记法）:
C10H10N2O2
化学文摘社编号:
分子量:
190.20
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
99%
assay
99%
InChI
1S/C10H10N2O2/c1-10(7-5-3-2-4-6-7)8(13)11-9(14)12-10/h2-6H,1H3,(H2,11,12,13,14)
SMILES string
CC1(NC(=O)NC1=O)c2ccccc2
InChI key
JNGWGQUYLVSFND-UHFFFAOYSA-N
mp
199-201 °C (lit.)
functional group
phenyl
separation technique
chiral
Application
Reactant for synthesis of:
Beta-amino alcohols as inhibitors of anti-tubercular target N-acetyltransferase
Chlorohydantoins
Specific MMP inhibitors
Beta-amino alcohols as inhibitors of anti-tubercular target N-acetyltransferase
Chlorohydantoins
Specific MMP inhibitors
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Elizabeth Fullam et al.
Bioorganic & medicinal chemistry letters, 21(4), 1185-1190 (2011-01-22)
The synthesis and inhibitory potencies of a novel series of β-amino alcohols, based on the hit-compound 3-[3'-(4''-cyclopent-2'''-en-1'''-ylphenoxy)-2'-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined.
Pirkle WH and Gan KZ.
Journal of Chromatography A, 790(1), 65-71 (1997)
Daniel C Whitehead et al.
Tetrahedron letters, 50(6), 656-658 (2010-02-17)
A simple and efficient methodology for the preparation of N-chlorinated hydantoins is presented. These versatile chlorenium sources were isolated in high yield after a simple recrystallization. Among the ten examples are the first chiral N-chlorohydantoins.
B Chankvetadz et al.
Journal of pharmaceutical and biomedical analysis, 15(9-10), 1577-1584 (1997-06-01)
The techniques for a dynamic and permanent reversal of the electroosmotic flow (EOF) were used for the reversal of the enantiomer migration order (EMO) of neutral and cationic analytes in chiral capillary electrophoresis (CE). Native beta-Cd and an anionic CD
Adriana Bakalova et al.
European journal of medicinal chemistry, 38(6), 627-632 (2003-07-02)
The interaction of cis-dichlorodiaminplatinum(II) (cis-DDP) with 2,4-imidazolidenedione-5-methyl-5-phenyl was studied. The method of preparation of the new Pt(II) complex consisted in precipitation of chloride ions from cis-DDP via a diaqua complex and reaction with the ligand in water-organic media. On the
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