190357
(R)-(-)-2-苯甘氨醇
98%, for peptide synthesis
别名:
(R)-2-氨基-2-苯乙醇, D-(-)-α-苯甘氨醇
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关于此项目
线性分子式:
C6H5CH(NH2)CH2OH
化学文摘社编号:
分子量:
137.18
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
260-287-5
MDL number:
Beilstein/REAXYS Number:
2935848
产品名称
(R)-(-)-2-苯甘氨醇, 98%
InChI key
IJXJGQCXFSSHNL-QMMMGPOBSA-N
InChI
1S/C8H11NO/c9-8(6-10)7-4-2-1-3-5-7/h1-5,8,10H,6,9H2/t8-/m0/s1
SMILES string
N[C@@H](CO)c1ccccc1
assay
98%
optical activity
[α]24/D −31.7°, c = 0.76 in 1 M HCl
optical purity
ee: 99% (GLC)
reaction suitability
reaction type: solution phase peptide synthesis
mp
75-77 °C (lit.)
application(s)
peptide synthesis
Quality Level
Application
作为合成的结构单元使用的手性 β-氨基醇。
本氨基醇可用于由三氟丙酮酸乙酯制备手性亚胺或噁唑烷。然后，可将这些中间体用于合成 α-三氟甲基脯氨酸的两种对映体。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Tetrahedron Letters, 45, 5287-5287 (2004)
Grégory Chaume et al.
Organic letters, 8(26), 6123-6126 (2006-12-15)
[Structure: see text] A concise synthesis of both enantiomers of alpha-Tfm-proline and (S)-alpha-Tfm-prolinol from ethyl trifluoropyruvate is reported. The key step is a diastereoselective allylation reaction of ethyl trifluoropyruvate and (R)-phenylglycinol-based oxazolidines or imine. The lactone obtained by cyclization of
Amedjkouh, M.; Westerlund, K.
Tetrahedron Letters, 45, 5175-5175 (2004)
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