197327
S-乙酰巯基丁二酸酐
96%
别名:
S-乙酰巯基琥珀酸酐, SAMSA
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关于此项目
经验公式（希尔记法）:
C6H6O4S
化学文摘社编号:
分子量:
174.17
NACRES:
NA.23
PubChem Substance ID:
UNSPSC Code:
12162002
EC Number:
230-135-2
MDL number:
InChI key
AHTFMWCHTGEJHA-UHFFFAOYSA-N
InChI
1S/C6H6O4S/c1-3(7)11-4-2-5(8)10-6(4)9/h4H,2H2,1H3
SMILES string
CC(=O)SC1CC(=O)OC1=O
assay
96%
mp
83-86 °C (lit.)
storage temp.
2-8°C
Quality Level
General description
S-乙酰巯基丁二酸酐是一种胺反应性试剂，含有巯基。当被胺亲核试剂攻击时，酸酐区域打开，形成胺键。但是，在该开环反应过程中，形成了游离的羧酸根基团，使分子带负电。电荷逆转影响蛋白质的活性和分子的构象。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Introduction of sulfhydryl groups into proteins using acetylmercaptosuccinic anhydride
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Archives of Biochemistry and Biophysics, 96(3), 605-612 (1932)
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Bioconjugate chemistry, 1(6), 400-410 (1990-11-01)
Ricin A chain immunotoxins disulfide cross-linked with conventional, sterically unhindered reagents have unsatisfactorily short circulating life times in vivo. (Acetylthio)succinic anhydride, a thiolating reagent with partial steric hindrance of the sulfur atom, does not remedy this situation. Sulfosuccinimidyl N-[3-(acetylthio)-3-methylbutyryl]-beta- alaninate
Fluorescent labeling of hormone receptors in viable cells: preparation and properties of highly fluorescent derivatives of epidermal growth factor and insulin.
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Proceedings of the National Academy of Sciences of the USA, 75(5), 2135-2139 (1978)
Monica A Serban et al.
Biomacromolecules, 8(9), 2821-2828 (2007-08-19)
Hyaluronan (HA) derivatives containing thiol-reactive electrophilic esters were prepared to react with thiol-modified macromolecules to give cross-linker-free hydrogels. Specifically, HA was converted to two haloacetate derivatives, HA bromoacetate (HABA) and HA iodoacetate (HAIA). In cytotoxicity assays, these reactive macromolecules predictably
Hermanson GT et al.
Bioconjugate Techniques null
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