205206
2-氨基-5-溴-6-甲基-4-嘧啶醇
97%
别名:
2-氨基-5-溴-6-甲基-4-咆嘧啶
方案
97%
mp
244-246 °C (lit.)
官能团
bromo
SMILES字符串
Cc1nc(N)nc(O)c1Br
InChI
1S/C5H6BrN3O/c1-2-3(6)4(10)9-5(7)8-2/h1H3,(H3,7,8,9,10)
InChI key
ADLWOFHKMXUDKF-UHFFFAOYSA-N
一般描述
2-Amino-5-bromo-6-methyl-4-pyrimidinol induced high levels of serum interferon in mice.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
D A Stringfellow et al.
Journal of interferon research, 1(1), 1-14 (1980-01-01)
The interferon inducing characteristics of a new series of 6-phenyl pyrimidinol compounds are described and compared against a previously identified pyrimidine, 2-amino-5-bromo-6-methyl-4-pyrimidinol (ABMP). Interestingly, a split in ability to induce interferon but not in vivo antiviral activity was observed in
D A Stringfellow
Antimicrobial agents and chemotherapy, 17(3), 455-460 (1980-03-01)
Prostaglandins enhanced the interferon response and therapeutic activity of interferon inducers in Friend leukemia virus-infected mice. A similar enhancement in interfron responsiveness but not antiviral activity was observed in mice infected with rapidly acute viruses.
Antineoplastic properties of pyrimidinone interferon inducers.
D A Stringfellow
Advances in enzyme regulation, 19, 335-348 (1980-01-01)
P S Morahan et al.
Antiviral research, 15(3), 241-254 (1991-03-01)
The question of whether interferon alpha/beta is the common mechanism of antiviral action of synthetic immunomodulators was investigated in B6C3F1 mice infected with Semliki Forest virus. Mice were treated with various concentrations of normal sheep serum or potent anti-alpha/beta interferon
M V Merritt et al.
Immunopharmacology, 5(1), 49-64 (1982-10-01)
We have used spin labeling, fluorescence polarization, and chemical analysis to characterize membrane properties of thymocytes from mice treated with immunomodulatory drugs. The number of thymocytes was reduced 90-95% by treatment of 6-9 week old mice with hydrocortisone acetate (HCA)
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