205656
N-乙酰普鲁卡因胺 盐酸盐
99%
别名:
N-乙酰普卡胺 盐酸盐, NAPA, 乙酰卡尼 盐酸盐
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关于此项目
线性分子式:
4-(CH3CONH)C6H4CONHCH2CH2N(C2H5)2·HCl
化学文摘社编号:
分子量:
313.82
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
251-831-2
MDL number:
assay
99%
mp
184-186 °C (lit.)
storage temp.
2-8°C
SMILES string
Cl[H].CCN(CC)CCNC(=O)c1ccc(NC(C)=O)cc1
InChI
1S/C15H23N3O2.ClH/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19;/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19);1H
InChI key
IYEWBJUCJHKLHD-UHFFFAOYSA-N
General description
The GLC assay procedure was developed to study the stability of N-acetylprocainamide hydrochloride (acecainide hydrochloride) in rat feed.
Biochem/physiol Actions
III 类抗心律失常药。通过降低延时的外向钾电流、稍微降低钙电流以及稍微抑制内向整流钾电流来增大动作电位的持续时间。这是普鲁卡因胺的活性代谢物，不会导致全身性红斑狼疮。
作用于钾电流的 III 类抗心律失常药。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J E Carter et al.
Journal of pharmaceutical sciences, 69(12), 1439-1440 (1980-12-01)
An extraction and GLC assay procedure was developed for quantitation of procainamide hydrochloride and acecainide hydrochloride in rat feed. 4-Amino-N-[2-(dipropylamino)ethyl]benzamide hydrochloride was synthesized and utilized as an internal standard. The assay has good precision and accuracy and was used to
Y L He et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 13(3), 303-308 (2001-06-01)
The dosage regimen of a drug eliminated predominantly through the kidney need to be adjusted for the patients with renal disease. The objective of the present study was to establish a quantitative approach to precisely predicting the renal clearances of
K Okumura et al.
Clinical pharmacology and therapeutics, 61(5), 509-517 (1997-05-01)
We studied the genotypes of polymorphic N-acetyltransferase (NAT2) in 145 Japanese subjects by the polymerase chain reaction-restriction fragment length polymorphism method. The rapid-type NAT2*4 was expressed at a higher frequency (68.6%) than the slow-type genes with specific point mutations (NAT2*6A
S D Nelson et al.
The Journal of pharmacology and experimental therapeutics, 273(1), 315-319 (1995-04-01)
Ischemic zone refractoriness and conduction delay respond differently to infarct healing and, hypothetically, may exert discordant influences on the electrophysiologic action of different classes of antiarrhythmic drugs. This study evaluated the influence of infarct healing on the electrophysiologic effects of
Relative efficacy of haemoperfusion, haemodialysis and CAPD in the removal of procainamide and NAPA in a patient with severe procainamide toxicity.
C L Low et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 11(5), 881-884 (1996-05-01)
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