206571
6-甲氧基-8-硝基喹啉
99%
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关于此项目
经验公式（希尔记法）:
C10H8N2O3
化学文摘社编号:
分子量:
204.18
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
201-633-7
MDL number:
Assay:
99%
Form:
powder
InChI key
MIMUSZHMZBJBPO-UHFFFAOYSA-N
InChI
1S/C10H8N2O3/c1-15-8-5-7-3-2-4-11-10(7)9(6-8)12(13)14/h2-6H,1H3
SMILES string
COc1cc([N+]([O-])=O)c2ncccc2c1
assay
99%
form
powder
mp
158-160 °C (lit.)
functional group
nitro
Application
6-Methoxy-8-nitroquinoline was used in the synthesis of:
- 6-methoxy-8-aminoquinoline, metabolite of primaquine
- 6-methoxy-8-hydroxylaminoquinoline
- 2-substituted/2,5-disubstituted-6-methoxy-8-nitroquinolines
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Suryanarayana Vangapandu et al.
Bioorganic & medicinal chemistry, 12(10), 2501-2508 (2004-04-28)
We report in vitro antimycobacterial properties of ring-substituted quinolines (series 1-4) constituting 56 analogues against drug-sensitive and drug-resistant M. tuberculosis H37Rv strains. The most effective compounds 2h (R1 = R2 = c-C6H11, R3 = NO2, series 1) and 13g (R1
L J Bolchoz et al.
The Journal of pharmacology and experimental therapeutics, 297(2), 509-515 (2001-04-17)
Primaquine is an important antimalarial agent because of its activity against exoerythrocytic forms of Plasmodium spp. However, methemoglobinemia and hemolytic anemia are dose-limiting side effects of primaquine therapy that limit its efficacy. These hemotoxicities are thought to be mediated by
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