grade
reagent grade
assay
98%
mp
132-135 °C (lit.)
density
1.335 g/mL at 25 °C (lit.)
SMILES string
NC(N)=O
InChI
1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
InChI key
XSQUKJJJFZCRTK-UHFFFAOYSA-N
Application
用于蛋白质变性以及作为不溶性或变性蛋白的温和增溶剂。可用于从已由 6M 盐酸胍变性的样品(如包涵体)复性蛋白质。可与盐酸胍和二硫苏糖醇 (DTT) 一起用于复性变性蛋白以恢复其天然或活性形式。
Other Notes
This product has been replaced by U1250-Sigma-Aldrich | Urea, ReagentPlus®, ≥99.5%, pellets | NH2CONH2
Legal Information
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Frederik B Pruijn et al.
Journal of medicinal chemistry, 48(4), 1079-1087 (2005-02-18)
The extravascular diffusion of antitumor agents is a key determinant of their therapeutic activity, but the relationships between physicochemical properties of drugs and their extravascular transport are poorly understood. It is well-known that drug lipophilicity plays an important role in
Lei Du-Cuny et al.
Bioorganic & medicinal chemistry, 17(19), 6983-6992 (2009-09-08)
Computational modeling continues to play an important role in novel therapeutics discovery and development. In this study, we have investigated the use of in silico approaches to develop inhibitors of the pleckstrin homology (PH) domain of AKT (protein kinase B).
Alex Avdeef et al.
Journal of medicinal chemistry, 53(9), 3566-3584 (2010-04-09)
The study aimed to predict effective human jejunal permeability (P(eff)) using a biophysical model based on parametrized paracellular, aqueous boundary layer, and transcellular permeabilities, and the villus-fold surface area expansion factor (k(VF)). Published human jejunal data (119 P(eff), 53 compounds)