217085
4′,6-二脒基-2-苯基吲哚 二盐酸盐
98%
别名:
2-（4-氨基苯基）-6-吲哚甲酰胺 二盐酸盐, DAPI 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C16H15N5 · 2HCl
化学文摘社编号:
分子量:
350.25
EC Number:
249-186-7
UNSPSC Code:
41116130
PubChem Substance ID:
Beilstein/REAXYS Number:
4894417
MDL number:
assay
98%
fluorescence
λex 340 nm; λem 488 nm (nur DAPI), λex 364 nm; λem 454 nm (DAPI-DNA-Komplex)
storage temp.
−20°C
SMILES string
Cl.Cl.NC(=N)c1ccc(cc1)-c2cc3ccc(cc3[nH]2)C(N)=N
InChI
1S/C16H15N5.2ClH/c17-15(18)10-3-1-9(2-4-10)13-7-11-5-6-12(16(19)20)8-14(11)21-13;;/h1-8,21H,(H3,17,18)(H3,19,20);2*1H
InChI key
FPNZBYLXNYPRLR-UHFFFAOYSA-N
Application
在琼脂糖凝胶中染色DNA，DAPI比溴化乙锭敏感几倍。
在琼脂糖凝胶中染色DNA，DAPI比溴化乙锭敏感几倍。它可用于DNA的光足迹图谱，通过对双链复合体的特殊可视化检测印迹应用中的退火探针，并使用流式细胞分析术研究DNA中的变化并分析凋亡过程中的DNA含量。DAPI染色也是一种敏感和特异的支原体检测方法。
Forms highly fluorescent complexes with DNA from various sources.
Biochem/physiol Actions
DNA的细胞渗透性荧光小沟结合探针。与双链DNA的小沟（富含AT的DNA优先）结合，形成稳定的复合物，其发出的荧光比单独的DAPI高约20倍。
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signalword
Warning
hcodes
Hazard Classifications
Skin Irrit. 2 - Skin Sens. 1A - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
法规信息
新产品
此项目有
Denise M Piscopo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(11), 4642-4656 (2013-03-15)
The thalamus is crucial in determining the sensory information conveyed to cortex. In the visual system, the thalamic lateral geniculate nucleus (LGN) is generally thought to encode simple center-surround receptive fields, which are combined into more sophisticated features in cortex
Sanna Koskiniemi et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(17), 7032-7037 (2013-04-11)
Rearrangement hotspot (Rhs) and related YD-peptide repeat proteins are widely distributed in bacteria and eukaryotes, but their functions are poorly understood. Here, we show that Gram-negative Rhs proteins and the distantly related wall-associated protein A (WapA) from Gram-positive bacteria mediate
Angus T Stock et al.
The Journal of experimental medicine, 211(5), 751-759 (2014-04-23)
Infection induces the expression of inflammatory chemokines that recruit immune cells to the site of inflammation. Whereas tissues such as the intestine and skin express unique chemokines during homeostasis, whether different tissues express distinct chemokine profiles during inflammation remains unclear.