218898
5-(二甲氨基)-1-萘磺酰胺
99%
别名:
DNSA, 丹磺酰胺
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关于此项目
线性分子式:
(CH3)2NC10H6SO2NH2
化学文摘社编号:
分子量:
250.32
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
215-854-1
Beilstein/REAXYS Number:
2217203
MDL number:
Assay:
99%
InChI key
TYNBFJJKZPTRKS-UHFFFAOYSA-N
InChI
1S/C12H14N2O2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3,(H2,13,15,16)
SMILES string
CN(C)c1cccc2c(cccc12)S(N)(=O)=O
assay
99%
mp
218-221 °C (lit.)
fluorescence
λex 280 nm; λem 470 nm (bound to carbon anhydrase), λem 580 in ethanol
functional group
amine
Quality Level
Application
5-（二甲基氨基）-1-萘磺酰胺（DNSA）作为起始试剂已被用于合成2,6-二取代的吡啶、6-取代的2,2′-联吡啶和6,6′-二取代的2,2-联吡啶。它还作为荧光探针用于测定溶液中人碳酸酐酶II-DNSA的浓度。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
A Jain et al.
Journal of medicinal chemistry, 37(13), 2100-2105 (1994-06-24)
This paper describes inhibitors for human carbonic anhydrase II (HCAII, EC 4.2.1.1) that bind with nanomolar dissociation constants. These inhibitors were developed by exploiting interactions with hydrophobic "patches" in the lip of the active site of this enzyme. These patches
Raymond Ziessel et al.
Organic letters, 5(14), 2397-2400 (2003-07-05)
[structure: see text] 2,6-Disubstituted pyridines, 6-substituted 2,2'-bipyridines, and 6,6'-disubstituted 2,2'-bipyridines are readily prepared under mild conditions from 5-(dimethylamino)-1-naphthalenesulfonamide chloride (DANS-Cl) and chloromethyl-nitronyl nitroxide (CH(2)Cl-NIT) starting materials and adequately functionalized building blocks. The syntheses of the pyridine molecules bearing two radicals
Jiangxiao Sun et al.
Analytical chemistry, 79(2), 416-425 (2007-01-16)
The interaction between the bovine pancrease trypsin (Tryp) and its competitive inhibitor benzamidine (1), in solution and the gas phase, is investigated using nanoflow electrospray ionization (nanoES) and Fourier transform ion cyclotron resonance mass spectrometry. In a recent study (Clark
Abir L Banerjee et al.
Biochemistry, 44(9), 3211-3224 (2005-03-02)
Benzenesulfonamide and iminodiacetate (IDA)-conjugated Cu(2+) independently interact at the active site and a peripheral site of carbonic anhydrases, respectively [Banerjee, A. L., Swanson, M., Roy, B. C., Jia, X., Haldar, M. K., Mallik, S., and Srivastava, D. K. (2004) J.
Harmen P Dijkstra et al.
Organic & biomolecular chemistry, 6(3), 523-531 (2008-01-26)
Reactive phosphonates are important probes to target the active site of serine hydrolases, one of the largest and most diverse family of enzymes. Developing such inhibitory probes is of special importance in activity based protein profiling, a strategy that is
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