219096
D -天冬氨酸
99%, for peptide synthesis, ReagentPlus®
别名:
(R)-(-)-氨基琥珀酸, (R)-2-氨基琥珀酸
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关于此项目
线性分子式:
HO2CCH2CH(NH2)CO2H
化学文摘社编号:
分子量:
133.10
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
217-234-6
MDL number:
Beilstein/REAXYS Number:
1723529
产品名称
D -天冬氨酸, ReagentPlus®, 99%
InChI key
CKLJMWTZIZZHCS-UWTATZPHSA-N
InChI
1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1
SMILES string
N[C@H](CC(O)=O)C(O)=O
product line
ReagentPlus®
assay
99%
form
powder
optical activity
[α]20/D −24°, c = 2.3 in 6 M HCl
optical purity
ee: 98% (GLC)
reaction suitability
reaction type: solution phase peptide synthesis
mp
>300 °C (lit.)
application(s)
peptide synthesis
Quality Level
Gene Information
rat ... Slc1a3(29483)
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Application
- 代谢组学分析鉴定差异代谢物作为急性心肌梗死的生物标志物：这项研究利用代谢组学来鉴定急性心肌梗死的生物标志物，展示了D-天冬氨酸在氨基酸代谢中的作用及其潜在的诊断应用。（Zhou等人，2024年）。
Legal Information
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Tadatoshi Kinouchi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(29), 3349-3352 (2011-09-29)
The formation and accumulation of D-aspartate residue (D-Asp) in proteins caused by oxidative stress leads to dysfunction and/or denaturation of proteins, and is consequently responsible for aging-related misfolding diseases such as cataracts, prion disease, and Alzheimer's disease. We sought to
Antimo D'Aniello
Brain research reviews, 53(2), 215-234 (2006-11-23)
D-Aspartic acid (d-Asp), an endogenous amino acid present in vertebrates and invertebrates, plays an important role in the neuroendocrine system, as well as in the development of the nervous system. During the embryonic stage of birds and the early postnatal
H Homma
Amino acids, 32(1), 3-11 (2006-06-07)
Recent investigations have shown that D-aspartate (D-Asp) plays an important physiological role(s) in the mammalian body. Here, several recent studies of free D-Asp metabolism in mammals, focusing on cellular localization in tissues, intracellular localization, biosynthesis, efflux, uptake and degradation are
Ikuhiko Noji et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(29), 3310-3316 (2011-07-12)
Unusual amino acid residues such as L-β-aspartyl (Asp), D-α-Asp, and D-β-Asp have been detected in proteins and peptides such as α-crystallin in the lens and β-amyloid in the brain. These residues increase with age, and hence they are associated with
Akifumi Oda et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(29), 3337-3343 (2011-08-30)
Molecular dynamics simulations of amyloid β(1-42) containing D-aspartic acid residues were performed using several continuous solvent models to investigate the usefulness of simulation methods for D-amino acid-containing proteins and peptides. Normal molecular dynamics simulations and replica exchange molecular dynamics simulations
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