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Merck
CN

219339

L-乙硫氨基酪酸

98%

别名:

L-2-氨基-4-(乙硫基)丁酸

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关于此项目

线性分子式:
C2H5SCH2CH2CH(NH2)CO2H
化学文摘社编号:
分子量:
163.24
UNSPSC Code:
12352103
PubChem Substance ID:
EC Number:
235-966-4
MDL number:
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InChI key

GGLZPLKKBSSKCX-YFKPBYRVSA-N

InChI

1S/C6H13NO2S/c1-2-10-4-3-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)/t5-/m0/s1

SMILES string

CCSCC[C@H](N)C(O)=O

assay

98%

optical activity

[α]22/D +21.7°, c = 1 in 1 M HCl

mp

280 °C (dec.) (lit.)

Biochem/physiol Actions

甲硫氨酸类似物,会干扰 DNA 的标准甲基化和其他甲基化途径,从而导致胰腺中毒和肝癌。但在动物研究中,也显示出与甲硫氨酸消耗的同步活动,以阻止甲硫氨酸依赖性肿瘤的生长和转移。

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

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Erik Alm et al.
Analytical and bioanalytical chemistry, 403(2), 443-455 (2012-03-01)
In (1)H NMR metabolomic datasets, there are often over a thousand peaks per spectrum, many of which change position drastically between samples. Automatic alignment, annotation, and quantification of all the metabolites of interest in such datasets have not been feasible.
Moncef Benkhalifa et al.
Fertility and sterility, 93(5), 1585-1590 (2009-04-14)
To investigate whether homocysteine, a well known inhibitor of methylation, which is produced after imprinting and other methylation processes, can be recycled to methionine in the oocyte, at least until the stage of maternal to zygotic transition (i.e., four- to
Yiannis N Kallis et al.
Gut, 60(4), 525-533 (2010-11-26)
In advanced liver damage, hepatic regeneration can occur through proliferation of a resident hepatic progenitor cell (HPC) population. HPCs are located within a designated niche in close association with myofibroblasts and bone marrow (BM) derived macrophages. Extra-cellular matrix (ECM) laminin
Shuntaro Ikeda et al.
The Journal of reproduction and development, 58(1), 91-97 (2011-11-05)
The roles of methionine metabolism in bovine preimplantation embryo development were investigated by using ethionine, an antimetabolite of methionine. In vitro produced bovine embryos that had developed to the 5-cell stage or more at 72 h after the commencement of
Joanne N Tonkin et al.
Stem cell research, 1(3), 195-204 (2009-04-23)
Liver progenitor (oval) cells have enormous potential in the treatment of patients with liver disease using a cell therapy approach, but their use is limited by their scarcity and the number of donor livers from which they can be derived.

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