220027
3-吲哚丙酸
ReagentPlus®, 99%
别名:
3-(3-吲哚基)丙酸, IPA, NSC 3252, NSC 47831, 吲哚-3-丙酸
质量水平
产品线
ReagentPlus®
方案
99%
表单
powder
mp
134-135 °C (lit.)
溶解性
ethanol: soluble 50 mg/mL, clear, yellow to orange
官能团
carboxylic acid
SMILES字符串
OC(=O)CCc1c[nH]c2ccccc12
InChI
1S/C11H11NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6H2,(H,13,14)
InChI key
GOLXRNDWAUTYKT-UHFFFAOYSA-N
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一般描述
3-吲哚丙酸是错误折叠的β-淀粉样蛋白（Abeta）聚集的一种有效抑制剂。通过三组分一锅法进行3-吲哚丙酸的组装已被报道。
应用
反应物用于制备：
- 独脚金内酯的荧光类似物
- 抗肿瘤剂
- 黑皮质素受体配体
- 免疫抑制剂
- 丙肝病毒抑制剂
- 组胺H4受体激动剂
- NR2B/NMDA受体拮抗剂
- CB1拮抗剂用于治疗肥胖症免疫抑制剂
- 抗细菌剂
- TGF-β受体结合抑制剂
法律信息
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Mauro F A Adamo et al.
Organic letters, 9(2), 303-305 (2007-01-16)
A three-component one-pot procedure (3-MC) was developed to assemble 3-indolepropionic acids from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography. [reaction: see text].
Xun Cheng et al.
Analytical chemistry, 77(21), 7012-7015 (2005-11-01)
Alzheimer's disease is the most common cause of the loss of cognitive function among the elderly, and the aggregation and deposition of misfolded beta-amyloid protein (Abeta) contribute to this progressive central nervous system decline. Therefore, compounds that inhibit or even
K L Borden et al.
European journal of biochemistry, 202(2), 459-470 (1991-12-05)
The antirepressor indole 3-propanoate has been shown by X-ray crystallography to bind in a different orientation compared with the natural corepressor for the tryp repressor, L-tryptophan (Lawson, C.L. & Sigler, P. B. (1988) Nature 333, 869-871). This suggests a simple
Burkhard Poeggeler et al.
PloS one, 5(4), e10206-e10206 (2010-04-28)
Aging is a multi-factorial process, however, it is generally accepted that reactive oxygen species (ROS) are significant contributors. Mitochondria are important players in the aging process because they produce most of the cellular ROS. Despite the strength of the free-radical
B Poeggeler et al.
Brain research, 815(2), 382-388 (1999-01-08)
The hydroxyl radical scavenging activity of indole-3-propionate was evaluated by kinetic competition studies with the hydroxyl radical trapping reagent 2,2'-azino-bis-(3-ethyl-benz-thiazoline-6-sulfonic acid) (ABTS) and by measuring hydroxyl radical-initiated lipid peroxidation in the rat striatum. Using ABTS, the indole was shown to
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