220027
3-吲哚丙酸
ReagentPlus®, 99%
别名:
3-(3-吲哚基)丙酸, IPA, NSC 3252, NSC 47831, 吲哚-3-丙酸
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关于此项目
经验公式（希尔记法）:
C11H11NO2
化学文摘社编号:
分子量:
189.21
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
212-600-1
Beilstein/REAXYS Number:
147733
MDL number:
Assay:
99%
Form:
powder
产品名称
3-吲哚丙酸, ReagentPlus®, 99%
InChI key
GOLXRNDWAUTYKT-UHFFFAOYSA-N
InChI
1S/C11H11NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6H2,(H,13,14)
SMILES string
OC(=O)CCc1c[nH]c2ccccc12
product line
ReagentPlus®
assay
99%
form
powder
mp
134-135 °C (lit.)
solubility
ethanol: soluble 50 mg/mL, clear, yellow to orange
functional group
carboxylic acid
Quality Level
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Application
反应物用于制备：
- 独脚金内酯的荧光类似物
- 抗肿瘤剂
- 黑皮质素受体配体
- 免疫抑制剂
- 丙肝病毒抑制剂
- 组胺H4受体激动剂
- NR2B/NMDA受体拮抗剂
- CB1拮抗剂用于治疗肥胖症免疫抑制剂
- 抗细菌剂
- TGF-β受体结合抑制剂
General description
3-吲哚丙酸是错误折叠的β-淀粉样蛋白（Abeta）聚集的一种有效抑制剂。通过三组分一锅法进行3-吲哚丙酸的组装已被报道。
Legal Information
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Mauro F A Adamo et al.
Organic letters, 9(2), 303-305 (2007-01-16)
A three-component one-pot procedure (3-MC) was developed to assemble 3-indolepropionic acids from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography. [reaction: see text].
Xun Cheng et al.
Analytical chemistry, 77(21), 7012-7015 (2005-11-01)
Alzheimer's disease is the most common cause of the loss of cognitive function among the elderly, and the aggregation and deposition of misfolded beta-amyloid protein (Abeta) contribute to this progressive central nervous system decline. Therefore, compounds that inhibit or even
B Poeggeler et al.
Brain research, 815(2), 382-388 (1999-01-08)
The hydroxyl radical scavenging activity of indole-3-propionate was evaluated by kinetic competition studies with the hydroxyl radical trapping reagent 2,2'-azino-bis-(3-ethyl-benz-thiazoline-6-sulfonic acid) (ABTS) and by measuring hydroxyl radical-initiated lipid peroxidation in the rat striatum. Using ABTS, the indole was shown to
Andrew W Woodward et al.
Plant physiology, 144(2), 976-987 (2007-04-24)
The ubiquitin-like protein RELATED TO UBIQUITIN (RUB) is conjugated to CULLIN (CUL) proteins to modulate the activity of Skp1-Cullin-F-box (SCF) ubiquitylation complexes. RUB conjugation to specific target proteins is necessary for the development of many organisms, including Arabidopsis (Arabidopsis thaliana).
Stéphanie Ortial et al.
Journal of medicinal chemistry, 49(9), 2812-2820 (2006-04-28)
The use of classical antioxidants is limited by their low bioavailabilities, and therefore, high doses are usually required to display significant protective activity. In a recent article (J. Med. Chem. 2003, 46, 5230) we showed that the ability of the
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