222429
5-甲基靛红
95%
别名:
5-甲基-2,3-吲哚二酮
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关于此项目
经验公式（希尔记法）:
C9H7NO2
化学文摘社编号:
分子量:
161.16
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
210-152-1
MDL number:
产品名称
5-甲基靛红, 95%
InChI key
VAJCSPZKMVQIAP-UHFFFAOYSA-N
InChI
1S/C9H7NO2/c1-5-2-3-7-6(4-5)8(11)9(12)10-7/h2-4H,1H3,(H,10,11,12)
SMILES string
Cc1ccc2NC(=O)C(=O)c2c1
assay
95%
form
solid
mp
180 °C (dec.) (lit.)
solubility
methanol: soluble 25 mg/mL, clear to slightly hazy, orange to red
functional group
ketone
Quality Level
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Application
5-Methylisatin was used as an internal standard during the determination of isatin (indole-2, 3-
dione) in body fluids by capillary column gas chromatography-mass spectrometry (GC—MS).
dione) in body fluids by capillary column gas chromatography-mass spectrometry (GC—MS).
Reactant for preparation of:
- Antimycobacterial agents
- Promoters of central nervous system (CNS) depression in mice
- Inhibitors of TAK1 kinase
- Anti-human immunodeficiency virus (HIV) agent
- Potent herpes simplex virus (HSV) inhibitors
- Antimicrobial agents
- IKKβ inhibitors
- Potential drug to combat human immunodeficiency virus-tuberculosis (HIV-TB) coinfection
- Cyclooxygenase 1/2 (COX-1/2) and 5-lipoxygenase (5-LOX) inhibitors
- Antibacterial and anticancer agents
General description
5-Methylisatin is an inhibitor of atrial natriuretic peptide (ANP) receptor coupled with guanylyl cyclase (GC).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M Dorneanu et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 100(1-2), 167-171 (1996-01-01)
This paper presents the synthesis of six hydrazones obtained by treating 5-methyl-isatin or 1-morpholino methyl-5-methyl-isatin with 3-(R-phenyl)-6-hydrazino-pyridazine (R = OCH3, Cl, Br) and two complex combination with copper, derived from 3-(p-anisyl-pyridazinyl)-hydrazone-5-methyl-indoline-2- one. The structure of the new compounds was confirmed
Yong Wang et al.
Bioorganic chemistry, 97, 103710-103710 (2020-03-09)
Moenomycin A, the well-known natural product inhibitor of peptidoglycan glycosyltransferase (PGT), is a large amphiphilic molecule of molecular mass of 1583 g/mol and its bioavailablity as a drug is relatively poor. In searching for small-molecule ligands with high inhibition ability targeting
A E Medvedev et al.
Biochemical pharmacology, 57(8), 913-915 (1999-03-23)
Isatin is an endogenous indole and an inhibitor of atrial natriuretic peptide (ANP) receptors coupled with particulate guanylyl cyclase (GC). In this study, several isatin analogues were tested as inhibitors of ANP-stimulated GC in rat brain and heart membranes. None
J M Halket et al.
Journal of chromatography, 562(1-2), 279-287 (1991-01-02)
A simple procedure based upon capillary column gas chromatography-mass spectrometry (GC-MS) is described for the detection and determination of isatin (indole-2,3-dione) in body fluids and tissues. After addition of 5-methylisatin as internal standard to urine or tissue homogenates, organic extracts
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