assay
≥99%
form
solid
bp
167 °C/11 mmHg (lit.)
mp
76-78 °C (lit.)
solubility
ethanol: soluble 50 mg/mL, clear, yellow-green
functional group
amide, phenyl
SMILES string
CNC(=O)c1ccccc1
InChI
1S/C8H9NO/c1-9-8(10)7-5-3-2-4-6-7/h2-6H,1H3,(H,9,10)
InChI key
NCCHARWOCKOHIH-UHFFFAOYSA-N
General description
N-甲基苯甲酰胺是一种有效的PDE10A（一种磷酸二酯酶，由于其仅在脑组织中丰富表达，因而具有明显的定位）抑制剂。
H van de Waterbeemd et al.
Journal of medicinal chemistry, 29(5), 600-606 (1986-05-01)
The electronic properties of orthopramides, a group of selective D-2 dopamine receptor antagonists, were investigated by calculating molecular electrostatic potentials (MEP) of model compounds with the ab initio STO-3G MO method. The various substitution patterns of the aromatic ring are
L Constantino et al.
Biochemical pharmacology, 44(4), 651-658 (1992-08-18)
The metabolism of N,N-dimethylbenzamides by phenobarbital-induced rat liver microsomes results in the formation of N-methylbenzamides and formaldehyde. The reaction proceeds via the formation of an intermediate N-hydroxymethyl-N-methylbenzamide, which, for the microsomal oxidation of N,N-dimethylbenzamide, was isolated and characterized. Confirmation of
Shih-Chung Huang et al.
Bioorganic & medicinal chemistry letters, 14(18), 4779-4782 (2004-08-25)
A series of N-methylbenzamide analogues (2-18) that is structurally derived from SR 48,968, a potent neurokinin-2 (NK(2)) receptor antagonist (pK(b)9.1), has been obtained using asymmetric synthesis. Isothiocyanato-N-methylbenzamide (10-12) and bromoacetamido-N-methylbenzamide derivatives (16-18) have been designed to serve as potential electrophilic
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 222798-10G | 04061831810165 |
| 222798-5G | 04061831810172 |