225525
2-氨基-2-去甲冰片羧酸
98%
别名:
2-氨基双环[2.2.1]庚烷-2-羧酸
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关于此项目
经验公式（希尔记法）:
C8H13NO2
化学文摘社编号:
分子量:
155.19
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C8H13NO2/c9-8(7(10)11)4-5-1-2-6(8)3-5/h5-6H,1-4,9H2,(H,10,11)/t5-,6+,8?/m1/s1
SMILES string
NC1(C[C@@H]2CC[C@H]1C2)C(O)=O
InChI key
MPUVBVXDFRDIPT-RSHNMJPRSA-N
assay
98%
mp
>300 °C (lit.)
Application
氨基酸跨膜转运的抑制剂。
法规信息
新产品
此项目有
Kohichi Yamauchi et al.
Cancer letters, 276(1), 95-101 (2008-12-09)
LAT1, a subunit of heterodimeric system L transporter responsible for transporting neutral amino acids into cells, has been investigated in several cancers because of its onco-fetal nature. Based on the studies of its functional inhibition, LAT1 has been proposed to
M M Sánchez del Pino et al.
The Journal of biological chemistry, 267(36), 25951-25957 (1992-12-25)
Endothelial cell membranes, the site of the blood-brain barrier, were obtained from the capillaries of cow brain. The luminal and abluminal membranes were separated by centrifugation on a discontinuous Ficoll gradient. Electron microscopy revealed that the membrane preparations consisted almost
Seung Jin Han et al.
The Journal of endocrinology, 212(3), 307-315 (2011-12-02)
2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) is an activator of glutamate dehydrogenase (GDH), which is a mitochondrial enzyme with an important role in insulin secretion. We investigated the effect of BCH on the high-glucose (HG)-induced reduction in glucose-stimulated insulin secretion (GSIS), the HG/palmitate
Ashwini L Chand et al.
Human reproduction (Oxford, England), 26(11), 3102-3108 (2011-09-15)
Little is known about metabolic processes in the developing ovarian follicle. Using mouse ovarian follicles, we investigated uptake of L-leucine by follicles at varying stages of maturity in the presence of insulin-like growth factor (IGF)-1. METHODS Mouse ovarian follicles were
Chun Sung Kim et al.
Biological & pharmaceutical bulletin, 31(6), 1096-1100 (2008-06-04)
L-Type amino acid transporter 1 (LAT1) is highly expressed in cancer cells to support their continuous growth and proliferation. We have examined the effect of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), an inhibitor of system L amino acid transporters, and the mechanism by
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