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Merck
CN

230138

噁唑

98%

别名:

1,3-恶唑, 3-氮杂呋喃

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关于此项目

经验公式(希尔记法):
C3H3NO
化学文摘社编号:
分子量:
69.06
Beilstein:
103851
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
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方案

98%

折射率

n20/D 1.425 (lit.)

沸点

69-70 °C (lit.)

mp

−87-−84 °C (lit.)

密度

1.05 g/mL at 25 °C (lit.)

SMILES字符串

c1cocn1

InChI

1S/C3H3NO/c1-2-5-3-4-1/h1-3H

InChI key

ZCQWOFVYLHDMMC-UHFFFAOYSA-N

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一般描述

恶唑是一大类杂环芳香化合物的母体分子。它是弱碱性的,可作为缺电子二烯用于Diels-Alder环加成反应。它可进行硝化、磺化、卤化、Friedel-Crafts烷化和酰化反应。

应用

噁唑可用于:
  • 分子内Diels–Alder(IMDA)环加成反应合成天然产物
  • 作为前体用于开环、亲核加成、再成环以及[2 + 2]、[3 + 2]和[4 + 2]环加成反应。

象形图

FlameCorrosion

警示用语:

Danger

危险声明

危险分类

Eye Dam. 1 - Flam. Liq. 2

储存分类代码

3 - Flammable liquids

WGK

WGK 3

闪点(°F)

66.2 °F - closed cup

闪点(°C)

19 °C - closed cup

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

危险化学品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Fengjiao Zhang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 140(1), 118-134 (2014-04-23)
The generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of renal ischemia/reperfusion injury, and many other pathological conditions. DNA strand breaks caused by ROS lead to the activation of poly(ADP-ribose)polymerase-1 (PARP-1), the excessive activation of which
Lori M Culberson et al.
Physical chemistry chemical physics : PCCP, 16(9), 3964-3972 (2014-01-22)
Bond breaking is a challenging problem in both experimental and theoretical chemistry, due to the transient nature and multi-configurational electronic structure of dissociating molecules. We use anion photodetachment to probe the diradical interactions in the ring-opening reaction of oxazole and
Systematic scientific study of 1, 3-oxazole derivatives as a useful lead for pharmaceuticals: A review
Joshi S, et al.
The pharma innovation journal, 6, 109-109 (2017)
J B Huppa et al.
The Journal of experimental medicine, 186(3), 393-403 (1997-08-04)
The T cell receptor for antigen (TCR) is a multisubunit complex that consists of at least seven polypeptides: the clonotypic, disulfide-linked alpha/beta heterodimer that is noncovalently associated with the invariant polypeptides of the CD3 complex (CD3-gamma, -delta, -epsilon) and zeta
Marta Cegłowska et al.
Marine drugs, 18(9) (2020-09-02)
Cyanobactins are a large family of ribosomally synthesized and post-translationally modified cyanopeptides (RiPPs). Thus far, over a hundred cyanobactins have been detected in different free-living and symbiotic cyanobacteria. The majority of these peptides have a cyclic structure. The occurrence of

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