230138
噁唑
98%
别名:
1,3-恶唑, 3-氮杂呋喃
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关于此项目
经验公式（希尔记法）:
C3H3NO
化学文摘社编号:
分子量:
69.06
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
206-020-8
Beilstein/REAXYS Number:
103851
MDL number:
Assay:
98%
InChI key
ZCQWOFVYLHDMMC-UHFFFAOYSA-N
InChI
1S/C3H3NO/c1-2-5-3-4-1/h1-3H
SMILES string
c1cocn1
assay
98%
refractive index
n20/D 1.425 (lit.)
bp
69-70 °C (lit.)
mp
−87-−84 °C (lit.)
density
1.05 g/mL at 25 °C (lit.)
Quality Level
General description
恶唑是一大类杂环芳香化合物的母体分子。它是弱碱性的，可作为缺电子二烯用于Diels-Alder环加成反应。它可进行硝化、磺化、卤化、Friedel-Crafts烷化和酰化反应。
Application
噁唑可用于：
- 分子内Diels–Alder(IMDA)环加成反应合成天然产物
- 作为前体用于开环、亲核加成、再成环以及[2 + 2]、[3 + 2]和[4 + 2]环加成反应。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
66.2 °F - closed cup
flash_point_c
19 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Haseen Ahmad et al.
European journal of medicinal chemistry, 208, 112759-112759 (2020-09-05)
Oxazole derivatives are important medicinal compounds which are inhibitors of various enzymes such as NPP1, NPP2, NPP3, tyrosine kinase, dipeptidyl-peptidase IV, cyclooxygenase-2, and protein tyrosine phosphatase. In this study, an extensive range of new biologically active biphenyl oxazole derivatives was
Maryna V Kachaeva et al.
Computational biology and chemistry, 74, 294-303 (2018-04-27)
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Oxazole as an Electron-Deficient Diene in the Diels-Alder Reaction
Suarez-Moreno G, et al.
Organic Letters, 13, 6358-6361 (2011)
Dawid Siodłak et al.
The journal of physical chemistry. B, 118(9), 2340-2350 (2014-02-18)
Oxazole ring occurs in numerous natural peptides, but conformational properties of the amino acid residue containing the oxazole ring in place of the C-terminal amide bond are poorly recognized. A series of model compounds constituted by the oxazole-amino acids occurring
Kristjan Bloudoff et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(1), 95-100 (2016-12-21)
Nonribosomal peptide synthetases (NRPSs) are a family of multidomain, multimodule enzymes that synthesize structurally and functionally diverse peptides, many of which are of great therapeutic or commercial value. The central chemical step of peptide synthesis is amide bond formation, which
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