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230766

(三甲基甲硅烷基)异硫氰酸酯

99%

别名:

三甲硅烷基异氰酸酯

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关于此项目

线性分子式:
(CH3)3SiNCS
化学文摘社编号:
2290-65-5
分子量:
131.27
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24853836
EC Number:
218-929-7
Beilstein/REAXYS Number:
1745262
MDL number:
MFCD00004797
Assay:
99%
Form:
liquid
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vapor density

>1 (vs air)

Quality Level

200

assay

99%

form

liquid

refractive index

n20/D 1.482 (lit.)

bp

143 °C (lit.)

mp

−32.8 °C (lit.)

density

0.931 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

C[Si](C)(C)N=C=S

InChI

1S/C4H9NSSi/c1-7(2,3)5-4-6/h1-3H3

InChI key

XLTUPERVRFLGLJ-UHFFFAOYSA-N

General description

三甲基甲硅烷基异硫氰酸酯（TMS-ITC）可与富勒烯混合的过氧化物C60(O)(OOtBu)4反应生成异硫氰酸酯衍生物C60(NCS)(OH)(OOtBu)4。TMS-ITC可与2-苄基氨基-5-甲基-3-苯基环戊-1-烯基羧酸乙酯发生缩合反应，生成1-苄基-5-甲基-7-苯基-2-硫代-1,2,3,5,6,7-六氢环戊嘧啶-4-酮。它可参与到N-取代的氮丙啶和环己烯氧化物的开环反应。

Application

异硫氰酸三甲基硅烷基酯已被用作氨基酸硫代乙内酰脲合成中的衍生试剂。

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

3 - Flammable liquids

wgk

WGK 3

flash_point_f

84.2 °F - closed cup

flash_point_c

29 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

危险化学品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000436606
0000436606
0000488258
0000488258
0000436605

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D H Hawke et al.
Analytical biochemistry, 166(2), 298-307 (1987-11-01)
A reinvestigation of the isothiocyanate-based chemistry for cyclic degradations of peptides and proteins revealed that the reagent trimethylsilylisothiocyanate (TMS-ITC) gives superior results in terms of coupling efficiency and lack of complicating side reactions. Acetic anhydride (10 min at various temperatures)
Noncatalyzed Addition of Trimethylsilyl Isothiocyanate to Aziridines and Cyclohexene Oxide.
Prusinowska N and Gawronski J.
Synthetic Communications, 39(15), 2795-2803 (2009)
J M Bailey et al.
Biochemistry, 29(12), 3145-3156 (1990-03-27)
Proteins and peptides can be sequenced from the carboxy terminus with isothiocyanate reagents to produce amino acid thiohydantoin derivatives. Previous studies in our laboratory indicated that the use of trimethylsilyl isothiocyanate (TMS-ITC) as a coupling reagent significantly improved the yields
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货号GTIN
230766-10G04061838782922
230766-50G04061838782939