234702
L-甲状腺素
99%
别名:
3,3′,5,5″-四碘代-L-甲状腺原氨酸, 3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸, T4
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线性分子式:
HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
化学文摘社编号:
分子量:
776.87
EC Number:
200-101-1
UNSPSC Code:
12352103
MDL number:
Beilstein/REAXYS Number:
2228515
assay
99%
mp
223 °C (dec.) (lit.)
SMILES string
N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
InChI
1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
InChI key
XUIIKFGFIJCVMT-LBPRGKRZSA-N
Gene Information
human ... TTR(7276)
Biochem/physiol Actions
L甲状腺素 (T4) 和三碘代-L-甲状腺原氨酸 (T3) 为含碘激素，由甲状腺卵泡细胞中的甲状腺球蛋白制备。这些激素对代谢率的刺激以及对生长发展的调节似乎归因于它们对 DNA 转录的作用，进而影响蛋白质的合成。
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Eva Fetter et al.
Reproductive toxicology (Elmsford, N.Y.), 57, 10-20 (2015-05-13)
Craniofacial malformations, reduced locomotion and induction of genes encoding for enzymes involved in thyroid hormone synthesis were assessed using methimazole and N-phenylthiourea in zebrafish embryos. Gene expression, the most sensitive endpoint (EC50_MMI=372-765μM, EC50_PTU=7.6-8.6μM), was analysed in wild-type and in a