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242039

1,2-二乙酰苯

Name: 1,2-二乙酰苯
Brand: ALDRICH

99%

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关于此项目

线性分子式:

C₆H₄(COCH₃)₂

化学文摘社编号:

704-00-7

分子量:

162.19

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24854529

EC Number:

211-877-6

Beilstein/REAXYS Number:

1862907

MDL number:

MFCD00008733

Assay:

99%

Form:

solid

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属性

Quality Level

200

assay

99%

form

solid

bp

110 °C/0.1 mmHg (lit.)

mp

39-41 °C (lit.)

solubility

dichloromethane: soluble 50 mg/mL, clear, colorless to yellow

fluorescence

λ_ex 355 nm; λ_em 455 nm (Amine adducts)

functional group

ketone

SMILES string

CC(=O)c1ccccc1C(C)=O

InChI

1S/C10H10O2/c1-7(11)9-5-3-4-6-10(9)8(2)12/h3-6H,1-2H3

InChI key

LVQFKRXRTXCQCZ-UHFFFAOYSA-N

说明

General description

1，2-二乙酰基苯是一种芳香烃，是神经毒性溶剂1，2-二乙苯的蛋白质反应性γ-二酮代谢产物。

Packaging

无底玻璃瓶。内含物装在插入的融合锥内。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Probing mechanisms of axonopathy. Part II: Protein targets of 2,5-hexanedione, the neurotoxic metabolite of the aliphatic solvent n-hexane.

Desire Tshala-Katumbay et al.

Toxicological sciences : an official journal of the Society of Toxicology, 107(2), 482-489 (2008-11-27)

Neuroprotein changes in the spinal cord of rodents with aliphatic gamma-diketone axonopathy induced by 2,5-hexanedione (2,5-HD) are compared with those reported previously in aromatic gamma-diketone-like axonopathy induced by 1,2-diacetylbenzene (1,2-DAB). Sprague-Dawley rats were treated intraperitoneally with 500 mg/kg/day 2,5-HD, equimolar

A new murine model of giant proximal axonopathy.

D D Tshala-Katumbay et al.

Acta neuropathologica, 109(4), 405-410 (2005-03-11)

The aromatic gamma-diketone 1,2-diacetylbenzene (1,2-DAB), the putative active metabolite of the organic solvent 1,2-diethylbenzene, forms blue-colored polymeric protein adducts and induces the formation of amyotrophic lateral sclerosis (ALS)-like giant, intraspinal neurofilamentous axonal swellings in Sprague Dawley rats. The pathogenetic mechanism

Organic solvent metabolite, 1,2-diacetylbenzene, impairs neural progenitor cells and hippocampal neurogenesis.

Min-Sun Kim et al.

Chemico-biological interactions, 194(2-3), 139-147 (2011-10-25)

1,2-Diacetylbenzene (DAB) is a neurotoxic minor metabolite of 1,2-diethylbenzene or naphthalene reaction product with OH radical. DAB causes central and peripheral neuropathies that lead to motor neuronal deficits. However, the potent effects and molecular mechanisms of DAB on neural progenitor

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全球贸易项目编号

货号	GTIN
242039-100MG	04061831819229
242039-500MG	04061831819236