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Merck
CN

246581

东莨菪内酯

95%

别名:

6-甲氧基伞形酮, 7-羟基-6-甲氧基-2H-1-苯并吡喃-2-酮, 7-羟基-6-甲氧基香豆素, 七叶亭-6-甲醚, 东莨菪亭, 东莨菪内酯, 柯阿托酸, 莨菪亭, 钩吻酸

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经验公式(希尔记法):
C10H8O4
化学文摘社编号:
分子量:
192.17
EC Number:
202-171-9
UNSPSC Code:
12352103
MDL number:
Beilstein/REAXYS Number:
156296
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InChI

1S/C10H8O4/c1-13-9-4-6-2-3-10(12)14-8(6)5-7(9)11/h2-5,11H,1H3

InChI key

RODXRVNMMDRFIK-UHFFFAOYSA-N

SMILES string

COc1cc2C=CC(=O)Oc2cc1O

assay

95%

mp

203-205 °C (lit.)

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Biochem/physiol Actions

东莨菪素通过促进 LPL 基因的转录,显著增强脂肪细胞中脂蛋白脂肪酶的活性。它还部分逆转 TNF-α 对 LPL 的抑制作用。

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Journal of natural products, 72(7), 1265-1268 (2009-07-04)
Six new prenylated isoflavanones named sophoronols A-F (1-6), together with eight phenolic constituents, were isolated from the roots of Sophora mollis. Their structures and stereochemistry were established by 1D and 2D NMR techniques, especially HMBC and NOESY as well as
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Journal of natural products, 71(2), 212-217 (2008-01-24)
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Journal of natural products, 69(12), 1769-1775 (2006-12-28)
Two new cyclopenta[b]benzofurans, aglaroxin A 1-O-acetate (2) and 3'-methoxyaglaroxin A 1-O-acetate (3), a new benzo[b]oxepine, 19,20-dehydroedulisone A (4), and five new cyclopenta[bc]benzopyrans, edulirin A (5), edulirin A 10-O-acetate (6), 19,20-dehydroedulirin A (7), isoedulirin A (8), and edulirin B (9), were
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Journal of natural products, 68(7), 1090-1093 (2005-07-26)
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