InChI key
PKSORSNCSXBXOT-UHFFFAOYSA-N
InChI
1S/C5Cl2F3N/c6-1-3(8)2(7)5(10)11-4(1)9
SMILES string
Fc1nc(F)c(Cl)c(F)c1Cl
assay
98%
form
liquid
refractive index
n20/D 1.478 (lit.)
bp
159-160 °C (lit.)
density
1.622 g/mL at 25 °C (lit.)
General description
The solid phase mid FTIR and FT-Raman spectra of 3,5-dichloro-2,4,6-trifluoropyridine has been recorded in the region of 3500-100 cm-1. 3,5-Dichloro-2,4,6-trifluoropyridine reacts with Ni(1,5,-cyclooctadiene)2 in the presence of triethylphosphine (PEt3) to yield trans-Ni(PEt3)2(C5ClF3N)Cl.
Application
3,5-Dichloro-2,4,6-trifluoropyridine has been used in the preparation of Avid AL, an affinity gel designed for the purification of immunoglobulin G.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
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Xiaoying Hui et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(7), 2496-2502 (2012-04-17)
This in vitro study determined the decontamination potential of soap and water, D-TAM skin cleanser, corn oil and the O'Dell reactive skin decontamination system to remove 3,5-dichloro-2,4,6-trifluoropyridine (DCTFP) from human skin after short exposure periods (10 and 30 min). The
Rapid intermolecular carbon-fluorine bond activation of pentafluoropyridine at nickel (0): Comparative reactivity of fluorinated arene and fluorinated pyridine derivatives.
Cronin L, et al.
Organometallics, 16(22), 4920-4928 (1997)
T T Ngo et al.
Journal of chromatography, 597(1-2), 101-109 (1992-04-24)
Avid AL is an affinity gel designed for the purification of immunoglobulin G (IgG). The gel was prepared by first reacting Sepharose with 3,5-dichloro-2,4,6-trifluoropyridine and 4-dimethylaminopyridine and then with 2-mercaptoethanol. The IgG purified by Avid AL is about 95% pure.
V C Lees et al.
Burns : journal of the International Society for Burn Injuries, 18(5), 423-425 (1992-10-01)
An example is reported of a burn caused by cutaneous exposure to 3,5-dichloro 2,4,6-trifluoropyridine (DCTFP) involving 25 per cent of the body surface. A striking feature was the development of the appearance of the burn over the first 72h postinjury.
T T Ngo
Journal of chromatography. B, Biomedical applications, 662(2), 351-356 (1994-12-09)
A derivative of aza-arenophilic gel having a dichlorosubstituent and an hydroxy ion as a capping nucleophile has been prepared. The properties of this gel in relation to IgG purification have been investigated in details. In the presence of high salt
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