253421
3-(2-碘乙酰氨基)-PROXYL
free radical
别名:
3-(2-碘乙酰氨基)-2,2,5,5-四甲基-1-吡咯烷基氧自由基
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选择尺寸
关于此项目
经验公式（希尔记法）:
C10H18IN2O2
化学文摘社编号:
分子量:
325.17
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352101
MDL number:
Form:
solid
InChI
1S/C10H18IN2O2/c1-9(2)5-7(12-8(14)6-11)10(3,4)13(9)15/h7H,5-6H2,1-4H3,(H,12,14)
SMILES string
CC1(C)CC(NC(=O)CI)C(C)(C)N1[O]
InChI key
OQIGMSGDHDTSFA-UHFFFAOYSA-N
form
solid
mp
162-164 °C (lit.)
functional group
amide, iodo
storage temp.
2-8°C
Quality Level
General description
3-(2-Iodoacetamido)-PROXYL is a free radical used as a spin probe in spin labeling techniques. This technique is helpful in investigating the dynamic aspects of molecular interactions of substances, proteins, lipids, and cell membranes.
Application
巯基基团特异性自旋标记物。应用包括研究经臭氧处理的人和牛红细胞膜蛋白以及定位肌纤维中的肌球蛋白亚片段。含有硫代磷酸二酯的 DNA 片段可用自旋标记物进行标记。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Christoph Gmeiner et al.
Physical chemistry chemical physics : PCCP, 19(41), 28360-28380 (2017-10-17)
A combined method, employing NMR and EPR spectroscopies, has demonstrated its strength in solving structures of protein/RNA and other types of biomolecular complexes. This method works particularly well when the large biomolecular complex consists of a limited number of rigid
Na Li et al.
Scientific reports, 10(1), 393-393 (2020-01-17)
Fowlpox virus resolvase (Fpr) is an endonuclease that cleaves a broad range of branched DNA structures, including the Holliday junction (HJ), with little sequence-specificity. To better understand the mechanisms underlying its relaxed substrate specificity, we determined the crystal structures of
Site directed nitroxide spin labeling of oligonucleotides for NMR and EPR studies
Shepherd NE, et al.
Tetrahedron, 71(5), 813-819 (2015)
Isabelle Lebars et al.
Nucleic acids research, 42(15), e117-e117 (2014-07-02)
Site-directed spin labeling is emerging as an essential tool to investigate the structural and dynamical features of RNA. We propose here an enzymatic method, which allows the insertion of a paramagnetic center at a specific position in an RNA molecule.
Congbao Kang et al.
Scientific reports, 3, 2985-2985 (2013-10-23)
FKBP38 regulates apoptosis through unique interactions with multiple regulators including Bcl-2. Interestingly, the peptidylprolyl isomerase activity of FKBP38 is only detectable when it binds to calcium-saturated calmodulin (CaM/Ca(2+)). This, in turn, permits the formation of a complex with Bcl-2. FKBP38
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