283746
4-(氨甲基)苯甲酸
97%, for peptide synthesis
别名:
PAMBA
Product Name
4-(氨甲基)苯甲酸, 97%
质量水平
方案
97%
表单
powder
反应适用性
reaction type: solution phase peptide synthesis
mp
≥300 °C (lit.)
应用
peptide synthesis
SMILES字符串
NCc1ccc(cc1)C(O)=O
InChI
1S/C8H9NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4H,5,9H2,(H,10,11)
InChI key
QCTBMLYLENLHLA-UHFFFAOYSA-N
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应用
4-（氨基甲基）苯甲酸（PAMBA）可用于合成：
- 钴羧酸膦酸酯。
- Apoptozole（Az），具有促进突变囊性纤维化跨膜传导调节因子（CFTR）氯通道活性的膜运输的细胞效力。
- 环肽，由 L-谷氨酸和 3-氨基苯甲酸组成，可用作各种阳离子和阴离子的受体。
- 生物活性肽，具有有效的 GPR54（G 蛋白偶联受体）激动活性。
其他说明
4-（氨基甲基）苯甲酸也是一种抗出血剂，用于治疗内出血。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Large increase in cation binding affinity of artificial cyclopeptide receptors by an allosteric effect.
Kubik S.
Journal of the American Chemical Society, 121(25), 5846-5855 (1999)
Marcus Tirado et al.
Journal of the American Society for Mass Spectrometry, 23(3), 475-482 (2012-01-06)
While recent studies have shown that for some peptides, such as oligoglycines and Leu-enkephalin, mid-sized b fragment ions exist as a mixture of oxazolone and macrocycle structures, other primary structure motifs, such as QWFGLM, are shown to exclusively give rise
Shingo Nakajima et al.
Molecular nutrition & food research, 56(5), 753-760 (2012-06-01)
Dietary peptides are potent stimulators of cholecystokinin (CCK) secretion, but the sensing mechanism in CCK-producing cells is poorly understood. Recently, it has been demonstrated that the calcium-sensing receptor (CaSR) mediates CCK secretion induced by amino acids. We investigated the role
Synthesis of model glycolipids having two long alkyl chains.
Z Zhang et al.
Carbohydrate research, 277(2), C1-C3 (1995-11-22)
Fmoc?based solid?phase synthesis of GPR54?agonistic pentapeptide derivatives containing alkene?and fluoroalkene?dipeptide isosteres.
Tomita K, et al.
Pept. Sci., 88(2), 272-278 (2007)
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